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Spine Tumors and Non-Spine Bone Metastases

  • Simon S. Lo
  • Yolanda Tseng
  • Lia M. Halasz
  • Edward Y. Kim
Chapter

Abstract

Spine tumor is a broad term including primary and metastatic tumors. Only a minority of spine tumors are primary tumors. They include the vertebral column (bone) tumors, intradural-extramedullary tumors, and intramedullary tumors.

Keywords

SBRT Spine Metastases Vertebra Bone 

References

  1. 1.
    Expert Panel on Radiation Oncology-Bone Metastases, Lo SS, Lutz ST, Chang EL, Galanopoulos N, Howell DD, Kim EY, Konski AA, Pandit-Taskar ND, Rose PS, Ryu S, Silverman LN, Sloan AE, Van Poznak C. ACR appropriateness criteria® spinal bone metastases. J Palliat Med. 2013;16(1):9–19.  https://doi.org/10.1089/jpm.2012.0376.
  2. 2.
    Lutz S, Berk L, Chang E, Chow E, Hahn C, Hoskin P, Howell D, Konski A, Kachnic L, Lo S, Sahgal A, Silverman L, von Gunten C, Mendel E, Vassil A, Bruner DW, Hartsell W, American Society for Radiation Oncology (ASTRO). Palliative radiotherapy for bone metastases: an ASTRO evidence-based guideline. Int J Radiat Oncol Biol Phys. 2011;79(4):965–76.  https://doi.org/10.1016/j.ijrobp.2010.11.026. Review.CrossRefPubMedGoogle Scholar
  3. 3.
    Cox BW, Spratt DE, Lovelock M, Bilsky MH, Lis E, Ryu S, Sheehan J, Gerszten PC, Chang E, Gibbs I, Soltys S, Sahgal A, Deasy J, Flickinger J, Quader M, Mindea S, Yamada Y. International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery. Int J Radiat Oncol Biol Phys. 2012;83(5):e597–605.  https://doi.org/10.1016/j.ijrobp.2012.03.009.CrossRefPubMedGoogle Scholar
  4. 4.
    Bilsky MH, Laufer I, Fourney DR, Groff M, Schmidt MH, Varga PP, Vrionis FD, Yamada Y, Gerszten PC, Kuklo TR. Reliability analysis of the epidural spinal cord compression scale. J Neurosurg Spine. 2010;13(3):324–8.  https://doi.org/10.3171/2010.3.SPINE09459.CrossRefPubMedGoogle Scholar
  5. 5.
    Fisher CG, DiPaola CP, Ryken TC, Bilsky MH, Shaffrey CI, Berven SH, Harrop JS, Fehlings MG, Boriani S, Chou D, Schmidt MH, Polly DW, Biagini R, Burch S, Dekutoski MB, Ganju A, Gerszten PC, Gokaslan ZL, Groff MW, Liebsch NJ, Mendel E, Okuno SH, Patel S, Rhines LD, Rose PS, Sciubba DM, Sundaresan N, Tomita K, Varga PP, Vialle LR, Vrionis FD, Yamada Y, Fourney DR. Reliability analysis of the epidural spinal cord compression scale. J Neurosurg Spine. 2010;13(3):324–8.  https://doi.org/10.3171/2010.3.SPINE09459.CrossRefGoogle Scholar
  6. 6.
    Redmond KJ, Robertson S, Lo SS, Soltys SG, Ryu S, McNutt T, Chao ST, Yamada Y, Ghia A, Chang EL, Sheehan J, Sahgal A. Consensus contouring guidelines for postoperative stereotactic body radiation therapy for metastatic solid tumor malignancies to the spine. Int J Radiat Oncol Biol Phys. 2017;97(1):64–74.  https://doi.org/10.1016/j.ijrobp.2016.09.014.CrossRefPubMedGoogle Scholar
  7. 7.
    Okoye CC, Patel RB, Hasan S, Podder T, Khouri A, Fabien J, Zhang Y, Dobbins D, Sohn JW, Yuan J, Yao M, Machtay M, Sloan AE, Miller J, Lo SS. Comparison of ray tracing and Monte Carlo calculation algorithms for thoracic spine lesions treated with CyberKnife-based stereotactic body radiation therapy. Technol Cancer Res Treat. 2016;15(1):196–202.  https://doi.org/10.1177/1533034614568026.CrossRefPubMedGoogle Scholar
  8. 8.
    Jabbari S, Gerszten PC, Ruschin M, Larson DA, Lo SS, Sahgal A. Stereotactic body radiotherapy for spinal metastases: practice guidelines, outcomes, and risks. Cancer J. 2016;22(4):280–9.  https://doi.org/10.1097/PPO.0000000000000205.CrossRefPubMedGoogle Scholar
  9. 9.
    Sahgal A, Larson DA, Chang EL. Stereotactic body radiosurgery for spinal metastases: a critical review. Int J Radiat Oncol Biol Phys. 2008;71(3):652–65.  https://doi.org/10.1016/j.ijrobp.2008.02.060. Review. Erratum in: Int J Radiat Oncol Biol Phys. 2009;74(1):323.CrossRefPubMedGoogle Scholar
  10. 10.
    Sahgal A, Weinberg V, Ma L, Chang E, Chao S, Muacevic A, Gorgulho A, Soltys S, Gerszten PC, Ryu S, Angelov L, Gibbs I, Wong CS, Larson DA. Probabilities of radiation myelopathy specific to stereotactic body radiation therapy to guide safe practice. Int J Radiat Oncol Biol Phys. 2013;85(2):341–7.  https://doi.org/10.1016/j.ijrobp.2012.05.007.CrossRefPubMedGoogle Scholar
  11. 11.
    Sahgal A, Ma L, Weinberg V, Gibbs IC, Chao S, Chang UK, Werner-Wasik M, Angelov L, Chang EL, Sohn MJ, Soltys SG, Létourneau D, Ryu S, Gerszten PC, Fowler J, Wong CS, Larson DA. Reirradiation human spinal cord tolerance for stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 2012;82(1):107–16.  https://doi.org/10.1016/j.ijrobp.2010.08.021.CrossRefPubMedGoogle Scholar
  12. 12.
    Miller JA, Balagamwala EH, Angelov L, Suh JH, Rini B, Garcia JA, Ahluwalia M, Chao ST. Spine stereotactic radiosurgery with concurrent tyrosine kinase inhibitors for metastatic renal cell carcinoma. J Neurosurg Spine. 2016;25(6):766–74.CrossRefPubMedGoogle Scholar
  13. 13.
    Kroeze SG, Fritz C, Hoyer M, Lo SS, Ricardi U, Sahgal A, Stahel R, Stupp R, Guckenberger M. Toxicity of concurrent stereotactic radiotherapy and targeted therapy or immunotherapy: a systematic review. Cancer Treat Rev. 2017;53:25–37.  https://doi.org/10.1016/j.ctrv.2016.11.013.CrossRefPubMedGoogle Scholar
  14. 14.
    Thibault I, Chang EL, Sheehan J, Ahluwalia MS, Guckenberger M, Sohn MJ, Ryu S, Foote M, Lo SS, Muacevic A, Soltys SG, Chao S, Gerszten P, Lis E, Yu E, Bilsky M, Fisher C, Schiff D, Fehlings MG, Ma L, Chang S, Chow E, Parelukar WR, Vogelbaum MA, Sahgal A. Response assessment after stereotactic body radiotherapy for spinal metastasis: a report from the SPIne response assessment in Neuro-Oncology (SPINO) group. Lancet Oncol. 2015;16(16):e595–603.  https://doi.org/10.1016/S1470-2045(15)00166-7. Review.CrossRefPubMedGoogle Scholar
  15. 15.
    Gerszten PC, Quader M, Novotny J Jr, Flickinger JC. Radiosurgery for benign tumors of the spine: clinical experience and current trends. Technol Cancer Res Treat. 2012;11(2):133–9.CrossRefPubMedGoogle Scholar
  16. 16.
    Gerszten PC, Burton SA, Ozhasoglu C, McCue KJ, Quinn AE. Radiosurgery for benign intradural spinal tumors. Neurosurgery. 2008;62(4):887–95; discussion 895–6.  https://doi.org/10.1227/01.neu.0000318174.28461.fc.CrossRefPubMedGoogle Scholar
  17. 17.
    Yamada Y, Laufer I, Cox BW, Lovelock DM, Maki RG, Zatcky JM, Boland PJ, Bilsky MH. Preliminary results of high-dose single-fraction radiotherapy for the management of chordomas of the spine and sacrum. Neurosurgery. 2013;73(4):673–80; discussion 680.  https://doi.org/10.1227/NEU.0000000000000083.CrossRefPubMedGoogle Scholar
  18. 18.
    Lockney DT, Shub T, Hopkins B, Lockney NA, Moussazadeh N, Lis E, Yamada Y, Schmitt AM, Higginson DS, Laufer I, Bilsky M. Spinal stereotactic body radiotherapy following intralesional curettage with separation surgery for initial or salvage chordoma treatment. Neurosurg Focus. 2017;42(1):E4.  https://doi.org/10.3171/2016.9.FOCUS16373.CrossRefPubMedGoogle Scholar
  19. 19.
    Wang XS, Rhines LD, Shiu AS, Yang JN, Selek U, Gning I, Liu P, Allen PK, Azeem SS, Brown PD, Sharp HJ, Weksberg DC, Cleeland CS, Chang EL. Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1-2 trial. Lancet Oncol. 2012;13(4):395–402.  https://doi.org/10.1016/S1470-2045(11)70384-9.CrossRefPubMedPubMedCentralGoogle Scholar
  20. 20.
    Garg AK, Shiu AS, Yang J, Wang XS, Allen P, Brown BW, Grossman P, Frija EK, McAleer MF, Azeem S, Brown PD, Rhines LD, Chang EL. Phase 1/2 trial of single-session stereotactic body radiotherapy for previously unirradiated spinal metastases. Cancer. 2012;118(20):5069–77.  https://doi.org/10.1002/cncr.27530.CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Yamada Y, Bilsky MH, Lovelock DM, Venkatraman ES, Toner S, Johnson J, Zatcky J, Zelefsky MJ, Fuks Z. High-dose, single-fraction image-guided intensity-modulated radiotherapy for metastatic spinal lesions. Int J Radiat Oncol Biol Phys. 2008 Jun 1;71(2):484–90.  https://doi.org/10.1016/j.ijrobp.2007.11.046.CrossRefPubMedGoogle Scholar
  22. 22.
    Guckenberger M, Mantel F, Gerszten PC, Flickinger JC, Sahgal A, Létourneau D, Grills IS, Jawad M, Fahim DK, Shin JH, Winey B, Sheehan J, Kersh R. Safety and efficacy of stereotactic body radiotherapy as primary treatment for vertebral metastases: a multi-institutional analysis. Radiat Oncol. 2014;9:226.  https://doi.org/10.1186/s13014-014-0226-2.CrossRefPubMedPubMedCentralGoogle Scholar
  23. 23.
    Sahgal A, Ames C, Chou D, Ma L, Huang K, Xu W, Chin C, Weinberg V, Chuang C, Weinstein P, Larson DA. Stereotactic body radiotherapy is effective salvage therapy for patients with prior radiation of spinal metastases. Int J Radiat Oncol Biol Phys. 2009 Jul 1;74(3):723–31.  https://doi.org/10.1016/j.ijrobp.2008.09.020.CrossRefPubMedGoogle Scholar
  24. 24.
    Gerszten PC, Germanwala A, Burton SA, Welch WC, Ozhasoglu C, Vogel WJ. Combination kyphoplasty and spinal radiosurgery: a new treatment paradigm for pathological fractures. J Neurosurg Spine. 2005;3(4):296–301.CrossRefPubMedGoogle Scholar
  25. 25.
    Laufer I, Iorgulescu JB, Chapman T, Lis E, Shi W, Zhang Z, Cox BW, Yamada Y, Bilsky MH. Local disease control for spinal metastases following “separation surgery” and adjuvant hypofractionated or high-dose single-fraction stereotactic radiosurgery: outcome analysis in 186 patients. J Neurosurg Spine. 2013;18(3):207–14.  https://doi.org/10.3171/2012.11.SPINE12111.CrossRefPubMedPubMedCentralGoogle Scholar
  26. 26.
    Al-Omair A, Masucci L, Masson-Cote L, Campbell M, Atenafu EG, Parent A, Letourneau D, Yu E, Rampersaud R, Massicotte E, Lewis S, Yee A, Thibault I, Fehlings MG, Sahgal A. Surgical resection of epidural disease improves local control following postoperative spine stereotactic body radiotherapy. Neuro-Oncology. 2013;15(10):1413–9.  https://doi.org/10.1093/neuonc/not101.CrossRefPubMedPubMedCentralGoogle Scholar
  27. 27.
    Bate BG, Khan NR, Kimball BY, Gabrick K, Weaver J. Stereotactic radiosurgery for spinal metastases with or without separation surgery. J Neurosurg Spine. 2015;22(4):409–15.  https://doi.org/10.3171/2014.10.SPINE14252.CrossRefPubMedGoogle Scholar
  28. 28.
    Lutz S, Balboni T, Jones J, Lo S, Petit J, Rich SE, Wong R, Hahn C. Palliative radiation therapy for bone metastases: Update of an ASTRO Evidence-Based Guideline. Pract Radiat Oncol. 2017;7(1):4–12.  https://doi.org/10.1016/j.prro.2016.08.001.CrossRefPubMedGoogle Scholar
  29. 29.
    Kim EY, Chapman TR, Ryu S, Chang EL, Galanopoulos N, Jones J, Kubicky CD, Lee CP, Teh BS, Traughber BJ, Van Poznak C, Vassil AD, Weber K, Lo SS. ACR appropriateness criteria® non-spine bone metastases. J Palliat Med. 2015;18(1):11–7.  https://doi.org/10.1089/jpm.2014.9395.CrossRefPubMedGoogle Scholar
  30. 30.
    Bedard G, McDonald R, Poon I, Erler D, Soliman H, Cheung P, Chung H, Chu W, Loblaw A, Chow E, Sahgal A. Stereotactic body radiation therapy for non-spine bone metastases—a review of the literature. Ann Palliat Med. 2016;5(1):58–66.  https://doi.org/10.3978/j.issn.2224-5820.2015.07.01. Review.CrossRefPubMedGoogle Scholar
  31. 31.
    Owen D, Laack NN, Mayo CS, Garces YI, Park SS, Bauer HJ, Nelson K, Miller RW, Brown PD, Olivier KR. Outcomes and toxicities of stereotactic body radiation therapy for non-spine bone oligometastases. Pract Radiat Oncol. 2014;4(2):e143–9.  https://doi.org/10.1016/j.prro.2013.05.006.CrossRefPubMedGoogle Scholar
  32. 32.
    Jhaveri PM, Teh BS, Paulino AC, Blanco AI, Lo SS, Butler EB, Amato RJ. A dose-response relationship for time to bone pain resolution after stereotactic body radiotherapy (SBRT) for renal cell carcinoma (RCC) bony metastases. Acta Oncol. 2012;51(5):584–8.  https://doi.org/10.3109/0284186X.2011.652741.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Simon S. Lo
    • 1
  • Yolanda Tseng
    • 1
  • Lia M. Halasz
    • 1
  • Edward Y. Kim
    • 1
  1. 1.Department of Radiation OncologyUniversity of Washington School of MedicineSeattleUSA

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