• Gregory D. Judy
  • Bhishamjit S. Chera


This chapter is included for a historical perspective as many do not perform brachytherapy anymore with the advent of more sophisticated linear accelerators. However, brachytherapy literature is the foundation on which SBRT is justified and brachytherapy can be utilized in a number of H&N sites to treat early-stage tumors, primarily in the oral cavity. Brachytherapy can be used as sole treatment or in combination with EBRT for definitive, small, early-stage tumors or in re-irradiation setting.


Head and neck Brachytherapy SBRT 


  1. 1.
    Guinot JL, Arribas L, Chust ML, et al. Lip cancer treatment with high dose rate brachytherapy. Radiother Oncol. 2003;69:113–5.CrossRefPubMedGoogle Scholar
  2. 2.
    Tombolini V, Bonanni A, Valeriani M, Zurlo A, Vitturini A. Brachytherapy for squamous cell carcinoma of the lip. The experience of the Institute of Radiology of the University of Rome “La Sapienza”. Tumori. 1998;84:478–82.CrossRefPubMedGoogle Scholar
  3. 3.
    Orecchia R, Rampino M, Gribaudo S, Negri GL. Interstitial brachytherapy for carcinomas of the lower lip. Results of treatment. Tumori. 1991;77:336–8.CrossRefPubMedGoogle Scholar
  4. 4.
    Marsiglia H, Haie-Meder C, Sasso G, Mamelle G, Gerbaulet A. Brachytherapy for T1-T2 floor-of-the-mouth cancers: the Gustave-Roussy Institute experience. Int J Radiat Oncol Biol Phys. 2002;52:1257–63.CrossRefPubMedGoogle Scholar
  5. 5.
    Lapeyre M, Hoffstetter S, Peiffert D, et al. Postoperative brachytherapy alone for T1–2N0 squamous cell carcinomas of the oral tongue and floor of mouth with close or positive margins. Int J Radiat Oncol Biol Phys. 2000;48:37–42.CrossRefPubMedGoogle Scholar
  6. 6.
    Pernot M, Hoffstetter S, Peiffert D, et al. Epidermoid carcinomas of the floor of mouth treated by exclusive irradiation: statistical study of a series of 207 cases. Radiother Oncol. 1995;35:177–85.CrossRefPubMedGoogle Scholar
  7. 7.
    Inoue T, Inoue T, Teshima T, et al. Phase III trial of high and low dose rate interstitial radiotherapy for early oral tongue cancer. Int J Radiat Oncol Biol Phys. 1996;36:1201–4.CrossRefPubMedGoogle Scholar
  8. 8.
    Matsuura K, Hirokawa Y, Fujita M, Akagi Y, Ito K. Treatment results of stage I and II oral tongue cancer with interstitial brachytherapy: maximum tumor thickness is prognostic of nodal metastasis. Int J Radiat Oncol Biol Phys. 1998;40:535–9.CrossRefPubMedGoogle Scholar
  9. 9.
    Wendt CD, Peters LJ, Delclos L, et al. Primary radiotherapy in the treatment of stage I and II oral tongue cancers: importance of the proportion of therapy delivered with interstitial therapy. Int J Radiat Oncol Biol Phys. 1990;18:1287–92.CrossRefPubMedGoogle Scholar
  10. 10.
    Nair MK, Sankaranarayanan R, Padmanabhan TK, Madhu CS. Oral verrucous carcinoma. Treatment with radiotherapy. Cancer. 1988;61:458–61.CrossRefPubMedGoogle Scholar
  11. 11.
    Levendag P, Nijdam W, Noever I, et al. Brachytherapy versus surgery in carcinoma of tonsillar fossa and/or soft palate: late adverse sequelae and performance status: can we be more selective and obtain better tissue sparing? Int J Radiat Oncol Biol Phys. 2004;59:713–24.CrossRefPubMedGoogle Scholar
  12. 12.
    Harrison LB, Lee HJ, Pfister DG, et al. Long term results of primary radiotherapy with/without neck dissection for squamous cell cancer of the base of tongue. Head Neck. 1998;20:668–73.CrossRefPubMedGoogle Scholar
  13. 13.
    Koutcher L, Lee N, Zelefsky M, et al. Reirradiation of locally recurrent nasopharynx cancer with external beam radiotherapy with or without brachytherapy. Int J Radiat Oncol Biol Phys. 2010;76:130–7.CrossRefPubMedGoogle Scholar
  14. 14.
    Lee AW, Foo W, Law SC, et al. Reirradiation for recurrent nasopharyngeal carcinoma: factors affecting the therapeutic ratio and ways for improvement. Int J Radiat Oncol Biol Phys. 1997;38:43–52.CrossRefPubMedGoogle Scholar
  15. 15.
    Langendijk JA, Poorter R, Leemans CR, de Bree R, Doornaert P, Slotman BJ. Radiotherapy of squamous cell carcinoma of the nasal vestibule. Int J Radiat Oncol Biol Phys. 2004;59:1319–25.CrossRefPubMedGoogle Scholar
  16. 16.
    Chobe R, McNeese M, Weber R, Fletcher GH. Radiation therapy for carcinoma of the nasal vestibule. Otolaryngol Head Neck Surg. 1988;98:67–71.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Gregory D. Judy
    • 1
    • 2
  • Bhishamjit S. Chera
    • 1
    • 2
  1. 1.Department of Radiation OncologyUniversity of North Carolina School of MedicineChapel HillUSA
  2. 2.Lineberger Comprehensive Cancer CenterUniversity of North Carolina School of MedicineChapel HillUSA

Personalised recommendations