How to Induce Arrhythmias with Adrenaline
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Adrenaline, also known as epinephrine, is a hormone produced by the adrenal gland that was first isolated in 1895 by the Polish physiologist Napoleon Cybulski. In normal individuals, endogenous plasma concentrations of adrenaline are less than 10 ng/L. This concentration increases tenfold during exercise and 50-fold during physiological or emotional stresses. After adrenaline is given intravenously, a significant increase in plasma concentrations appears within 1 min. In cardiac reanimation, a bolus of adrenaline can produce increased plasma concentrations as 10,000–100,000 ng/L.
- 1.Szablewski L. Glucose homeostasis and insulin resistance. Sharjah: Betham Science; 2011. p. 68.Google Scholar
- 7.Goldstein DS, Dionne R, Sweet J, Gracely R, Brewer B, Gregg R, et al. Circulatory, plasma-catecholamine, cortisol, lipid, and psychological responses to a real-life stress (third molar extractions)—effects of diazepam sedation and of inclusion of epinephrine with the local-anesthetic. Psychosom Med. 1982;44:259–72.CrossRefGoogle Scholar
- 8.Bell DR. Medical physiology: principles for clinical medicine. 3rd ed. Philadelphia: Lippincott Williams and Wilkins; 2009. p. 312.Google Scholar
- 13.Christensen NJ, Alberti KG, Alberti KG, Brandsborg O. Plasma catecholamines and blood substrate concentrations: studies in insulin induced hypoglycemia and after adrenaline infusions. Eur J Clin Investig. 1975;5:415–23.Google Scholar
- 20.Stellbrink C, Diem B, Schauerte P, Brehmer K, Schuett H, Hanrath P. Differential effects of atropine preexcitation by vagal stimulation or isoproterenol and isoproterenol on inducibility of atrioventricular nodal reentrant tachycardia. J Interv Card Electrophysiol. 2001;5:463–9.CrossRefGoogle Scholar