How to Induce Arrhythmias with Orciprenaline

  • Nihal El Kamar
  • Lazhare Naouar


Orciprenaline is a bronchodilator used for the treatment of asthma and COPD. The other name for orciprenaline is metaproterenol. It has a β2 selective effect with no effect on alpha receptors. It stimulates the smooth muscle in the bronchiole, uterus and arterioles supplying the skeletal muscle. Orciprenaline is a more specific β 2 agonist than isoproterenol hence causes less tachycardia and hypotension at equipotent doses.


  1. 1.
    Hatch F, McKellop K, Hansen G, et al. Relative bioavailability of metaproterenol in humans utilizing a single dose stable isotope approach. J Pharm Sci. 1986;9:886–90.CrossRefGoogle Scholar
  2. 2.
    Rona G, Chappel C, Zsoter T, et al. Myocardial lesions circulatory and electrocardiographic changes produced by isoproterenol in the dog. Rev Can Biol. 1959;18:83–94.PubMedGoogle Scholar
  3. 3.
    Hock C, Toh CCS, Khoo TH. Clinical trial of orciprenaline in bradyarrhythmias. Singapore Med J. 1975;16:100–5.Google Scholar
  4. 4.
    Parwani AS, Schroder A, Blaschke D, et al. Third- degree AV block sensitive to prednisolone 72 hour post ablation ov AVNRT. Clin Case Rep. 2017;5:671–4.CrossRefGoogle Scholar
  5. 5.
    Strohmer B, Hwang C. Ablation of postinfarction ventricular tachycardia guided by isolated diastolic potentials. Europace. 2003;5:375–80.CrossRefGoogle Scholar
  6. 6.
    Sinkovec M, Vrecar I, Sustar M, Pernat A, Rakovec P, et al. Electrophysiological and clinical characteristics of atrioventricular nodal reentrant tachycardia and long-term success of radiofrequency catheter ablation. Zdravniški vestnik. 2010;79:280–9.Google Scholar
  7. 7.
    Abd Al-Hassan A. Radiofrequency ablation of typical atrioventricular node reentry tachycardia in dual and multiple AV nodal pathways. Med J Babylon. 2015;3:745–54.Google Scholar
  8. 8.
    Weismuller P, Kuly S, Brandts B, et al. Is electrical stimulation during administration of catecholamines required for evaluation of success after ablation of atrioventricular node reentrant tachycardia? J Am Coll Cardiol. 2002;39:691–4.CrossRefGoogle Scholar
  9. 9.
    Shanks RG, Brick I, Hutchinson K, Roddie IC. Stimulation of adrenergic beta-receptors by orciprenaline. Br Med J. 1967;1:610.CrossRefGoogle Scholar
  10. 10.
    Rona G, Chapel C, Balazs T. An infarct-like myocardial lesion and other toxic manifestations produced by isoproterenol in the dog. Rev Can Biol. 1959;18:83.PubMedGoogle Scholar
  11. 11.
    Komadina KH, Carlson TA, Strollo PJ, et al. Electrophysiologic study of the effects of aminophylline and metaproterenol on canine myocardium. Chest. 1992;100:232–8.CrossRefGoogle Scholar
  12. 12.
    Kirchhof P, Klimas J, Fabritz L, et al. Stress and high heart rate provoke ventricular tachycardia in mice expressing triadin. J Mol Cell Cardiol. 2007;42:962–71.CrossRefGoogle Scholar
  13. 13.
    Gattiker R, Schmid E. Hemodynamic effects of dopamine, epinephrine and orciprenaline (Alupent) in patients early after cardiac surgery. Intensive Care Med. 1978;4:55–61.CrossRefGoogle Scholar
  14. 14.
    Pott C, Wegner F, Bogeholz N, Fischer A, et al. Supraventricular extrasystole due to 1:2 atrioventricular conduction: procedural characteristics and long term follow-up of slow pathway modulation. Eur Heart J. 2013;34(suppl 1_1):P2350.CrossRefGoogle Scholar
  15. 15.
    Weber HP, Kaltenbrunner W, Heinze A, et al. Laser catheter coagulation of atrial myocardium for ablation of atrioventricular node reentrant tachycardia. Eur Heart J. 1997;18:487–95.CrossRefGoogle Scholar
  16. 16.
    Heinroth KM, Kattenbeck K, Sabenow I. Multiple AV nodal pathways in patients with AV nodal reentrant tachycardia-more common than expected ? Europace. 2002;4:375–82.CrossRefGoogle Scholar
  17. 17.
    Reents T, Springer B, Hessling G, et al. Long-term follow-up after cryoablation for adolescent atrioventricular nodal reentrant tachycardia: recurrence is not predictable. Europace. 2012;14:1629–33.CrossRefGoogle Scholar
  18. 18.
    Wojdyla-Hordynska A, Kowalsi O, Hordynski G, et al. The effect of radiofrequency catheter ablation of frequent premature ventricular complexes and arrhythmia burden on left ventricular function. Kardiol Pol. 2017;75:698–704.CrossRefGoogle Scholar
  19. 19.
    Frey B, Kreiner G, Fitsch S, Veit S, Gossinger HD. Successful treatment of idiopathic left ventricular outflow tract tachycardia by catheter ablation or minimally invasive surgical cryoablation. PACE. 2000;23:870–6.CrossRefGoogle Scholar
  20. 20.
    Brunelli M, Raffa S, Grobe A. Residual condution after pulmonary vein isolation with a circular multielectrode radiofrequency catheter ablation: the role of adenosine and orciprenaline during a prolonged observation time. Int J Cardiol. 2013;168:4122–31.CrossRefGoogle Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Nihal El Kamar
    • 1
  • Lazhare Naouar
    • 1
  1. 1.Augusta-Krankenhaus, Klinik fur KardiologieDusseldorfGermany

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