How to Induce Arrhythmias with Aminophylline?
Aminophylline, a methylxanthine, is a 2:1 combination between theophylline and ethylenediamine. The 2:1 ratio improves the solubility of the product. Compared to theophylline, aminophylline is a less potent nonselective adenosine receptor antagonist and phosphodiesterase inhibitor. The effects on the sinus node are reduction in the corrected sinus node recovery time and sinoatrial conduction time. The effect on the atrial tissue is reduction in the atrial refractory period. The effect on the AV node was decrease in the Wenckebach point and AH time. The effect on the His-Purkinje system is reduction in the HV conduction time. There was no change in the ventricular refractory period.
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