• John J. HalperinEmail author


The term neuroborreliosis encompasses nervous system infection with any borrelia. However, it is typically used to describe nervous system Lyme disease (infection with Borrelia burgdorferi) and the closely related disorders in Europe caused by B. garinii and B. afzelii. Common clinical presentations of these tick-borne infections include one or more of the following: lymphocytic meningitis, cranial neuritis, painful radiculitis, and other forms of mononeuropathy multiplex. Diagnosis rests primarily on serologic testing—two-tier testing in serum and demonstration of intrathecal antibody production, comparing cerebrospinal fluid to serum. Treatment with several weeks of oral doxycycline is effective in most patients with neuroborreliosis with parenteral treatment primarily for severe involvement, particularly with parenchymal central nervous system involvement.


Lyme disease Neuroborreliosis Meningitis Cranial neuritis Neuropathy Treatment Diagnosis Borrelia burgdorferi B. afzelii B. garinii Intrathecal antibody 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NeurosciencesOverlook Medical CenterSummitUSA
  2. 2.Sidney Kimmel Medical College of Thomas Jefferson UniversityPhiladelphiaUSA

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