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Tumor Angiogenesis

  • Domenico Ribatti
Chapter

Abstract

In 1907, Goldman described the characteristics of tumor vessels including their dilatation, accelerated proliferation and irregular arrangement. In 1939, Ide et al. were the first to suggest that tumors release specific factors capable of stimulating the growth of blood vessels. In 1945, Algire and Chalkley were the first to appreciate that growing malignancies could continuously elicit new capillary growth from the host. They used a transparent chamber implanted in a cat’s skin to study the vasoproliferative reaction secondary to a wound or implantation of normal or neoplastic tissues. They showed that the vasoproliferative response induced by tumor tissues was more substantial and earlier than that induced by normal tissues or following a wound. They found that capillaries arose from the host and that endothelial proliferation appeared as early as 3 days after implantation, weheras in wounds it did not begin for 6 days. Moreover, differentiation of vessels in vessels into arterioles and venules was not evident and the authors believe that an oustainding characteristic of the tumor cells was its capacity to elicit continued growth of new capillaries from the host: “This characteristic of the tumor cell, rather than some hypothetical capacity for autonomous growth inherent within the cell, is, from the standpoint of the host, an important expression of neoplastic change”. They concluded that the growth of a tumor is closely connected to the development of an intrinsic vascular network.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Domenico Ribatti
    • 1
  1. 1.Department of Basic Medical Sciences, Neurosciences and Sensory OrgansUniversity of Bari Medical SchoolBariItaly

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