Oxidative Stress and Hearing Loss
Oxidative stress is considered as a central factor in acquired hearing loss. This chapter provides an introduction to the fundamental concepts of oxidative stress as well as an overview of cochlear oxidative stress pathways activated by risk factors of auditory dysfunction. It also discusses the susceptibility of the inner ear to oxidative damage, the intracellular redox sensitive mechanisms that facilitate cytotoxicity, and the cochlear targets of oxidative stress. Special focus is given to cochlear oxidative stress induced by exposure to environmental factors, such as noise, heavy metals, and organic solvents, ototoxic drugs/agents, such as aminoglycosides, cisplatin, and radiation, and aging. Potential biomarkers of oxidative stress and the utility of targeting cochlear oxidative stress to mitigate acquired hearing loss are discussed. Finally, recent developments in this field, including therapeutic compounds and strategies employed to target different steps in the oxidative stress signaling pathways as well as potential challenges to these approaches are discussed.
KeywordsOxidative stress Free radicals Nitrative stress Ototoxicity Cisplatin Hearing loss
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