• Shawn Babiuk


Capripoxviruses are double-stranded DNA viruses that have hairpin loop ends which are similar to other poxviruses. Unfortunately, these regions have not yet been sequenced to directly compare these regions to the hairpin loop ends of other poxviruses. The genomes of members of the Capripoxvirus genus are approximately 150 Kbp in length. Capripoxviruses are similar to other poxviruses, with the genome being complex and encoding many genes. Before full-genome sequencing was available, restriction fragment analysis was used to compare and classify the relationship between capripoxviruses (Black et al. 1986; Gershon and Black 1988) and to some orthopoxvirus members (Gershon et al. 1989). These studies demonstrated the relationship between capripoxviruses and other poxviruses. The full-genome sequencing of lumpy skin disease virus together with bioinformatics revealed that lumpy skin disease virus encodes 156 putative genes (Tulman et al. 2001).


  1. Black DN, Hammond JM, Kitching RP (1986) Genomic relationship between capripoxviruses. Virus Res 5:277–292CrossRefPubMedGoogle Scholar
  2. Gershon PD, Black DN (1988) A comparison of the genomes of capripoxvirus isolates of sheep, goats, and cattle. Virology 164:341–349CrossRefPubMedGoogle Scholar
  3. Gershon PD, Ansell DM, Black DN (1989) A comparison of the genome organization of capripoxvirus with that of the orthopoxviruses. J Virol 63:4703–4708PubMedPubMedCentralGoogle Scholar
  4. Kara PD, Afonso CL, Wallace DB, Kutish GF, Abolnik C, Lu Z, Vreede FT, Taljaard LC, Zsak A, Viljoen GJ, Rock DL (2003) Comparative sequence analysis of the South African vaccine strain and two virulent field isolates of lumpy skin disease virus. Arch Virol 148:1335–1356PubMedGoogle Scholar
  5. Mathijs E, Vandenbussche F, Haegeman A, King A, Nthangeni B, Potgieter C, Maartens L, Van Borm S, De Clercq K (2016) Complete genome sequences of the Neethling-like lumpy skin disease virus strains obtained directly from three commercial live attenuated vaccines. Genome Announc 4:e01255-16CrossRefPubMedPubMedCentralGoogle Scholar
  6. Moss B (2001) Poxviridae: the viruses and their replication. In: Fields BN, Knipe DM, Howley PM, Chanock RM, Melnick JL, Monathy TP, Roizman B, Straus SE (eds) Fields virology, 4th edn. Lippincott, Williams and Wilkins, Philadelphia, PA, pp 2849–2883Google Scholar
  7. Tulman ER, Afonso CL, Lu Z, Zsak L, Kutish GF, Rock DL (2001) Genome of lumpy skin disease virus. J Virol 75:7122–7130CrossRefPubMedPubMedCentralGoogle Scholar
  8. Tulman ER, Afonso CL, Lu Z, Zsak L, Sur JH, Sandybaev NT, Kerembekova UZ, Zaitsev VL, Kutish GF, Rock DL (2002) The genomes of sheeppox and goatpox viruses. J Virol 76:6054–6061CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Shawn Babiuk
    • 1
    • 2
  1. 1.Canadian Food Inspection Agency, National Centre for Foreign Animal DiseaseWinnipegCanada
  2. 2.University of ManitobaWinnipegCanada

Personalised recommendations