Bioactive Organoselenium Compounds and Therapeutic Perspectives

  • Eder João Lenardão
  • Claudio Santi
  • Luca Sancineto


After 1984, when ebselen was tested as a mimetic of the key antioxidant enzyme glutathione peroxidase (GPx), a plethora of organoselenium compounds have been synthesized and tested for various pharmacological purposes. Here a brief overview of the most important achievements in bioactive organoselenium small molecules is given, with particular emphasis on the GPx-like as well as to the antiviral, antibacterial, antifungal, and antiprotozoal activities. While historical information is given to help contextualize the content, the most recent literature is comprehensively discussed.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Eder João Lenardão
    • 1
  • Claudio Santi
    • 2
  • Luca Sancineto
    • 3
  1. 1.CCQFA - LASOLUniversidade Federal de PelotasPelotasBrazil
  2. 2.Department of Pharmaceutical SciencesUniversità degli Studi di PerugiaPerugiaItaly
  3. 3.Section of Heterorganic ChemistryCentre of Molecular and Macromolecular Studies, Polish Academy of SciencesŁódźPoland

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