Advertisement

Fever in Non-infectious Diseases

  • A. Sahib El-Radhi
Chapter

Abstract

  • Fever is commonly found in children with haematological disorders, of which sickle-cell anaemia is the most common.

  • An important cause of febrile illnesses in children with haemolytic disorders is infection with human parvovirus B19 (HPV B19).

  • Children with cancer are often neutropenic, and any associated fever needs urgent medical attention because of underlying serious bacterial infections, which may be responsible for 50% of deaths.

  • Fever in children with cancer may be due either to the disease (neoplastic fever) or to infection. The diagnosis of neoplastic fever should only be considered after exclusion of infection.

  • Early administration of antibiotics to children with febrile neutropenia prior to confirming the infection has improved the survival in these children.

  • In rheumatology, children with juvenile idiopathic arthritis have the highest incidence of fever. Children may present with persistent fever of unknown origin and are often subjected to intensive investigations, including many trials of antibiotics and occasionally laparotomy.

  • In Kawasaki disease, fever has diagnostic and prognostic importance: higher temperature during days 10–13 of the disease and its continuation for more than 14 days are a risk factor associated with coronary involvement.

  • Fever following vaccination is common and usually trivial. It is not a contraindication to further doses of vaccines.

Keywords

Fever in haematological Neoplastic fever Rheumatological diseases CNS tumours Leukaemia Lymphoma Kawasaki disease 

References

Haematology

  1. 1.
    Platt OS, Thorington BD, Brambilla DJ, et al. Pain in sickle cell disease: rates and risk factors. N Engl J Med. 1991;325:11–6.CrossRefGoogle Scholar
  2. 2.
    Smith WK, Zhao H, Hodinka RL, et al. Epidemiology of human parvovirus B19 in children with sickle cell anaemia. Blood. 2004;103:422–7.CrossRefGoogle Scholar
  3. 3.
    Powars D, Overturf GD, Wilkins J. Commentary in sickle cell and SC disease. J Pediatr. 1983;103:242–4.CrossRefGoogle Scholar
  4. 4.
    McIntosh S, Rocks Y, Ritchey K, et al. Fever in young children with sickle cell disease. J Pediatr. 1980;96:199–204.CrossRefGoogle Scholar
  5. 5.
    Smith AW, Hendrichse RG, Harrison C, et al. Iron deficiency anaemia and its response to oral iron: report of a study in rural Gambian children treated at home by their mothers. Ann Trop Paediatr. 1989;9:17–23.CrossRefGoogle Scholar
  6. 6.
    Gera T, Sachdev HPS. Effects of iron supplementation on incidence of infectious illness in children: systematic review. BMJ. 2002;325:1142–4.CrossRefGoogle Scholar
  7. 7.
    McKee LC. Fever in megaloblastic anaemia. South Med J. 1979;72:1423–4.CrossRefGoogle Scholar
  8. 8.
    Igbal MP. Megaloblastic anaemia in a hospital-based population. Med Sci Res. 2000;28:45–7.Google Scholar
  9. 9.
    Welborn JL, Hersch J. Blood transfusion reactions: which are life-threatening and which are not? Postgrad Med. 1991;90:125–38.CrossRefGoogle Scholar

Neoplastic Diseases

  1. 10.
    Sasse EC, Sasse AD, Bandalise SR, et al. Colony-stimulating factors for prevention of myelosuppressive therapy. The Cochrane Library. 2006;4.Google Scholar
  2. 11.
    Lobell M, Boggs DR, Wintrope MM. The clinical significance of fever in Hodgkin’s disease. Arch Intern Med. 1966;117:335–42.CrossRefGoogle Scholar

Rheumatic Diseases

  1. 12.
    Calabro JJ, Marchesano JM. Fever associated with juvenile rheumatoid arthritis. N Engl J Med. 1967;276:11–8.CrossRefGoogle Scholar
  2. 13.
    Tucker LB, et al. Adult- and childhood-onset systemic lupus erythematosus: a comparison of onset, clinical features, serology, and outcome. Br J Rheumatol. 1997;36:1343.CrossRefGoogle Scholar
  3. 14.
    Love LA, Leff RL, Fraser DD, et al. A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogeneous patient groups. Medicine (Baltimore). 1991;70:360–74.CrossRefGoogle Scholar
  4. 15.
    Koran G, Lavi S, Rose V, et al. Kawasaki disease: review of risk factors for coronary aneurysms. J Pediatr. 1986;108:388–92.CrossRefGoogle Scholar
  5. 16.
    Salo E, Pelkonen P, Pettay O. Outbreak of Kawasaki disease in Finland. Acta Paediatr Scand. 1986;75:75–80.CrossRefGoogle Scholar

Fever after Vaccination

  1. 17.
    Miller E. Overview of recent clinical trials of acellular pertussis vaccines. Biologicals. 1999;27:79–86.CrossRefGoogle Scholar
  2. 18.
    Tozzi AE, Olin P. Common side effects in the Italian and Stockholm I trials. Dev Biol Stand. 1997;89:105–8.PubMedGoogle Scholar

Sarcoidosis

  1. 19.
    Hoffman AL, Millman N, Byq KE. Childhood sarcoidosis in Denmark 1979-1994: incidence, clinical features and laboratory results at presentation in 48 children. Acta Pediatr. 2004;93:30–6.CrossRefGoogle Scholar
  2. 20.
    Pietinalho A, Ohmichi M, Hiraga Y, et al. The mode of presentation of sarcoidosis in Finland and in Hokkaido, Japan. Sarcoidosis Vasc Diffuse Lung Dis. 1996;13:159–66.PubMedGoogle Scholar
  3. 21.
    Nolan JP, Klatskin G. The fever of sarcoidosis. Ann Intern Med. 1964;61:455–61.CrossRefGoogle Scholar

Familial Mediterranean Fever

  1. 22.
    McDermott MF. A common pathway in periodic fever syndromes. Trends Immunol. 2004;25:457–60.CrossRefGoogle Scholar
  2. 23.
    Zemer D, Pras M, Sohar E, et al. Colchicine in the prevention and treatment of the amyloidosis of FMF. N Engl J Med. 1986;314:1001–5.CrossRefGoogle Scholar

Sweet Syndrome

  1. 24.
    Sweet RD. An acute febrile neutrophilic dermatosis. Br J Dermatol. 1964;76:349–56.CrossRefGoogle Scholar
  2. 25.
    Boatman BW, Talor RC, Klein LE, et al. Sweet’s syndrome in children. South Med J. 1994;87:193–6.CrossRefGoogle Scholar

Familial Dysautonomia

  1. 26.
    Axelrod FB, Proges RF, Sein ME. Neonatal recognition of familial dysautonomia. J Pediatr. 1987;110:946–8.CrossRefGoogle Scholar
  2. 27.
    Tirosh I, Hoffer V, Finkelstein Y, et al. Heat stroke in familial dysautonomia. Pediatr Neurol. 2003;29:164:66.CrossRefGoogle Scholar

Fever Associated with Teething

  1. 28.
    Guthrie L. Teething. BMJ. 1908;2:486.CrossRefGoogle Scholar
  2. 29.
    Illingworth RS. The normal child. 3rd ed. London: Churchill; 1964. p. 77–80.Google Scholar
  3. 30.
    Jaber I, Cohen IJ, Mor A. Fever associated with teething. Arch Dis Child. 1992;67:233–4.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • A. Sahib El-Radhi
    • 1
  1. 1.Chelsfield Park HospitalOrpingtonUK

Personalised recommendations