Histology: The Different Points of View on Barret’s Esophagus

  • Vincenzo Villanacci
  • Karel Geboes
  • Tiziana Salviato
  • Gabrio Bassotti


In 1950, Dr. Norman Barrett published a paper in the British Journal of Surgery with the title “Chronic peptic ulcer of the oesophagus and oesophagitis.” This was later followed by another paper, entitled “The lower esophagus, lined by columnar epithelium.” The history of what is now called “Barrett’s esophagus” is characterized by different definitions over time and in different geographic areas, and by different ideas between different medical professions. In the present review, the current view of this condition is presented, based upon endoscopy and pathology and consensus between different medical specialties. The pathogenesis is discussed and guidelines for the diagnosis are proposed. The diagnosis, based upon endoscopy and histology, is important because of the association between Barrett’s esophagus and cancer. Early detection is therefore essential and the criteria for the diagnosis of dysplasia are reviewed including recommendations for the endoscopic procedures.


Barrett’s esophagus Endoscopy Intestinal metaplasia Dysplasia Cancer development 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Vincenzo Villanacci
    • 1
  • Karel Geboes
    • 2
  • Tiziana Salviato
    • 3
  • Gabrio Bassotti
    • 4
  1. 1.Institute of Pathology, Spedali CiviliBresciaItaly
  2. 2.Department of PathologyUniversity Hospitals Leuven, KU LeuvenLeuvenBelgium
  3. 3.Department of PathologyUniversity of Trieste—School of MedicineTriesteItaly
  4. 4.Gastroenterology and Hepatology Section, Department of MedicineUniversity of Perugia—School of MedicinePerugiaItaly

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