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Indications for Resection of Preinvasive Cystic Neoplasms of the Intra- and Extrahepatic Bile Ducts

  • Jad Abou-Khalil
  • Flavio G. RochaEmail author
Chapter

Abstract

Liver cysts are common findings typically identified incidentally on imaging and are almost universally benign in nature. However, in addition to those due to an infectious etiology, premalignant cysts can arise that require prompt evaluation and treatment. These include mucinous cystic neoplasms, intraductal papillary neoplasms of the bile duct, tubulopapillary neoplasms, choledochal cysts, and ciliated hepatic foregut cysts. The risk of cancer progression in these lesions can be varied. This chapter will describe the etiology, diagnosis, and management of these cysts with an emphasis on indications for resection.

Keywords

Cystic neoplasm Biliary cyst Cholangiocarcinoma Papillary Choledochal cyst 

References

  1. 1.
    Takano Y, Nagahama M, Yamamura E, Maruoka N, Mizukami H, Tanaka J-I, et al. Prolapse into the bile duct and expansive growth is characteristic behavior of mucinous cystic neoplasm of the liver: report of two cases and review of the literature. Clin J Gastroenterol. 2015;8(3):148–55. 05/0801/09/received 04/16/accepted. PubMed PMID: PMC4481294.CrossRefGoogle Scholar
  2. 2.
    Nakanuma Y. A novel approach to biliary tract pathology based on similarities to pancreatic counterparts: is the biliary tract an incomplete pancreas? Pathol Int. 2010;60(6):419–29. PubMed PMID: 20518896. Epub 2010/06/04. eng.CrossRefGoogle Scholar
  3. 3.
    Zen Y, Pedica F, Patcha VR, Capelli P, Zamboni G, Casaril A, et al. Mucinous cystic neoplasms of the liver: a clinicopathological study and comparison with intraductal papillary neoplasms of the bile duct. Mod Pathol. 2011;24(8):1079–89. PubMed PMID: 21516077. Epub 2011/04/26. eng.CrossRefGoogle Scholar
  4. 4.
    Erdogan D, Lamers WH, Offerhaus GJ, Busch OR, Gouma DJ, van Gulik TM. Cystadenomas with ovarian stroma in liver and pancreas: an evolving concept. Dig Surg. 2006;23(3):186–91. PubMed PMID: 16837797. Epub 2006/07/14. eng.CrossRefGoogle Scholar
  5. 5.
    Yi B, Cheng Q-B, Jiang X-Q, Liu C, Luo X-J, Dong H, et al. A special growth manner of intrahepatic biliary cystadenoma. World J Gastroenterol. 2009;15(48):6134–6. 12/2810/22/received 11/18/revised 11/25/accepted. PubMed PMID: PMC2797675.CrossRefGoogle Scholar
  6. 6.
    Kim HJ, Yu ES, Byun JH, Hong S-M, Kim KW, Lee JS, et al. CT differentiation of mucin-producing cystic neoplasms of the liver from solitary bile duct cysts. Am J Roentgenol. 2013;202(1):83–91. 2014/01/01.CrossRefGoogle Scholar
  7. 7.
    Zen Y, Jang KT, Ahn S, Kim DH, Choi DW, Choi SH, et al. Intraductal papillary neoplasms and mucinous cystic neoplasms of the hepatobiliary system: demographic differences between Asian and western populations, and comparison with pancreatic counterparts. Histopathology. 2014;65(2):164–73. PubMed PMID: 24456415. Epub 2014/01/25. eng.CrossRefGoogle Scholar
  8. 8.
    Ishak KG, Willis GW, Cummins SD, Bullock AA. Biliary cystadenoma and cystadenocarcinoma: report of 14 cases and review of the literature. Cancer. 1977;39(1):322–38. PubMed PMID: 318915. Epub 1977/01/01. eng.CrossRefGoogle Scholar
  9. 9.
    Ahanatha Pillai S, Velayutham V, Perumal S, Ulagendra Perumal S, Lakshmanan A, Ramaswami S, et al. Biliary cystadenomas: a case for complete resection. HPB Surg. 2012;2012:501705. 06/2003/14/received04/30/revised 05/08/accepted. PubMed PMID: PMC3388282.CrossRefGoogle Scholar
  10. 10.
    Martel G, Alsharif J, Aubin J-M, Marginean C, Mimeault R, Fairfull-Smith RJ, et al. The management of hepatobiliary cystadenomas: lessons learned. HPB. 2013;15(8):617–22. 12/0608/21/received10/28/accepted. PubMed PMID: PMC3731583.CrossRefGoogle Scholar
  11. 11.
    Simo KA, McKillop IH, Ahrens WA, Martinie JB, Iannitti DA, Sindram D. Invasive biliary mucinous cystic neoplasm: a review. HPB. 2012;14(11):725–40. 01/20/received 06/08/accepted. PubMed PMID: PMC3482668.CrossRefGoogle Scholar
  12. 12.
    Wang M, Deng BY, Wen TF, Peng W, Li C, Trishul NM. An observational and comparative study on intraductal papillary mucinous neoplasm of the biliary tract and the pancreas from a Chinese cohort. Clin Res Hepatol Gastroenterol. 2016;40(2):161–8. PubMed PMID: 26823040. Epub 2016/01/30. eng.CrossRefGoogle Scholar
  13. 13.
    Rocha FG, Lee H, Katabi N, DeMatteo RP, Fong Y, D'Angelica MI, et al. Intraductal papillary neoplasm of the bile duct: a biliary equivalent to intraductal papillary mucinous neoplasm of the pancreas? Hepatology (Baltimore, Md). 2012;56(4):1352–60. PubMed PMID: 22504729. Epub 2012/04/17. eng.CrossRefGoogle Scholar
  14. 14.
    Wan XS, Xu YY, Qian JY, Yang XB, Wang AQ, He L, et al. Intraductal papillary neoplasm of the bile duct. World J Gastroenterol. 2013;19(46):8595–604. PubMed PMID: 24379576. Pubmed Central PMCID: PMC3870504. Epub 2014/01/01. eng.CrossRefGoogle Scholar
  15. 15.
    Arnaoutakis DJ, Kim Y, Pulitano C, Zaydfudim V, Squires MH, Kooby D, et al. Management of biliary cystic tumors: a multi-institutional analysis of a rare liver tumor. Ann Surg. 2015;261(2):361–7. PubMed PMID: 24509187. Pubmed Central PMCID: PMC4655107. Epub 2014/02/11. eng.CrossRefGoogle Scholar
  16. 16.
    Jung G, Park KM, Lee SS, Yu E, Hong SM, Kim J. Long-term clinical outcome of the surgically resected intraductal papillary neoplasm of the bile duct. J Hepatol. 2012;57(4):787–93. PubMed PMID: 22634127. Epub 2012/05/29. eng.CrossRefGoogle Scholar
  17. 17.
    Katabi N, Torres J, Klimstra DS. Intraductal tubular neoplasms of the bile ducts. Am J Surg Pathol. 2012;36(11):1647–55. PubMed PMID: 23073323. Epub 2012/10/18. eng.CrossRefGoogle Scholar
  18. 18.
    Sato Y, Osaka H, Harada K, Sasaki M, Nakanuma Y. Intraductal tubular neoplasm of the common bile duct. Pathol Int. 2010;60(7):516–9. PubMed PMID: 20594273. Epub 2010/07/03. eng.CrossRefGoogle Scholar
  19. 19.
    Schlitter AM, Jang KT, Kloppel G, Saka B, Hong SM, Choi H, et al. Intraductal tubulopapillary neoplasms of the bile ducts: clinicopathologic, immunohistochemical, and molecular analysis of 20 cases. Mod Pathol. 2015;28(9):1249–64. PubMed PMID: 26111977. Epub 2015/06/27. eng.CrossRefGoogle Scholar
  20. 20.
    Alonso-Lej F, Rever WB Jr, Pessagno DJ. Congenital choledochal cyst, with a report of 2, and an analysis of 94, cases. Int Abstr Surg. 1959;108(1):1–30. PubMed PMID: 13625059. Epub 1959/01/01. eng.PubMedGoogle Scholar
  21. 21.
    Todani T, Watanabe Y, Narusue M, Tabuchi K, Okajima K. Congenital bile duct cysts: classification, operative procedures, and review of thirty-seven cases including cancer arising from choledochal cyst. Am J Surg. 1977;134(2):263–9. PubMed PMID: 889044. Epub 1977/08/01. eng.CrossRefGoogle Scholar
  22. 22.
    Voyles CR, Smadja C, Shands WC, Blumgart LH. Carcinoma in choledochal cysts. Age-related incidence. Arch Surg (Chicago, IL: 1960). 1983;118(8):986–8. PubMed PMID: 6870530. Epub 1983/08/01. eng.Google Scholar
  23. 23.
    Soreide K, Soreide JA. Bile duct cyst as precursor to biliary tract cancer. Ann Surg Oncol. 2007;14(3):1200–11. PubMed PMID: 17187167. Epub 2006/12/26. eng.CrossRefGoogle Scholar
  24. 24.
    Ohashi T, Wakai T, Kubota M, Matsuda Y, Arai Y, Ohyama T, et al. Risk of subsequent biliary malignancy in patients undergoing cyst excision for congenital choledochal cysts. J Gastroenterol Hepatol. 2013;28(2):243–7. PubMed PMID: 22989043. Pubmed Central PMCID: PMC3816325. Epub 2012/09/20. eng.CrossRefGoogle Scholar
  25. 25.
    Bishop KC, Perrino CM, Ruzinova MB, Brunt EM. Ciliated hepatic foregut cyst: a report of 6 cases and a review of the English literature. Diagn Pathol. 2015;10:81. 06/3001/22/received 06/10/accepted. PubMed PMID: PMC4486693.CrossRefGoogle Scholar
  26. 26.
    Ben Ari Z, Cohen-Ezra O, Weidenfeld J, Bradichevsky T, Weitzman E, Rimon U, et al. Ciliated hepatic foregut cyst with high intra-cystic carbohydrate antigen 19-9 level. World J Gastroenterol. 2014;20(43):16355–8. 11/2103/28/received 05/25/revised 07/16/accepted. PubMed PMID: PMC4239529.CrossRefGoogle Scholar
  27. 27.
    Zhang X, Wang Z, Dong Y. Squamous cell carcinoma arising in a ciliated hepatic foregut cyst: case report and literature review. Pathol Res Pract. 2009;205(7):498–501. PubMed PMID: 19410383. Epub 2009/05/05. eng.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of SurgeryThe Ottawa HospitalOttawaCanada
  2. 2.Section of General, Thoracic and Vascular SurgeryVirginia Mason Medical CenterSeattleUSA

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