Nanosensors for Biomedical Applications: A Tutorial

  • Holly ClinganEmail author
  • Alex Laidlaw
  • Pilarisetty Tarakeshwar
  • Micah Wimmer
  • Antonio García
  • Vladimiro Mujica
Part of the Nanostructure Science and Technology book series (NST)


Nanoparticles coated with different kinds of molecules are currently designed and synthesized for several important applications, including catalysis, solar cells, and biomedical uses. A crucial molecular design variable is whether the nanoparticle exhibits plasmonic activity, e.g., the case of nanoparticles made of coinage metals, where no band gap is present, or if it rather behaves as a nano-semiconductor with a band gap, e.g., metal oxide nanoparticles. In this tutorial, we will discuss the literature for both plasmonic and non-plasmonic materials and our own recent theoretical and experimental work in two different showcases. First, we will present the example of using gold nanoparticles to monitor molecular sensing activity to follow changes in antibody/antigen binding through changes of the surface plasmon resonance (SPR) response. Second, we will discuss the case of surface-enhanced Raman resonance (SERS) in hybrid systems molecule-TiO2 nanoparticles and clusters, where the important physical quantity is the Raman signal to monitor the formation of chemical bonds and interfacial electron transfer processes.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Holly Clingan
    • 1
    Email author
  • Alex Laidlaw
    • 1
  • Pilarisetty Tarakeshwar
    • 1
  • Micah Wimmer
    • 1
  • Antonio García
    • 2
  • Vladimiro Mujica
    • 1
  1. 1.School of Molecular SciencesArizona State UniversityTempeUSA
  2. 2.Ira A. Fulton School of EngineeringArizona State UniversityTempeUSA

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