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Esophageal Squamous Cell Cancer: Pathogenesis and Epidemiology

  • Daniel Tong
  • Simon LawEmail author
Chapter

Abstract

Esophageal cancer is a highly lethal disease. Despite the rapidly increasing incidence of adenocarcinoma in last decades, squamous cell carcinoma remains the predominant cell type worldwide. The majority of squamous cell cancers are from Eastern populations. Risk factors for the development of esophageal squamous cell carcinoma differ between high and low incidence regions. Tobacco and alcohol intake are the two major risks factors for esophageal squamous cell carcinoma. They also have a synergistic effect; the mechanism of which is now better understood. Other dietary factors include lack of certain micronutrients such as vitamins and minerals, consumption of food with carcinogenic ingredients, eating habits and food preservation methods. Genetic factors, viral infection and other premalignant conditions also play a role. Studying epidemiology and pathogenesis of the disease allows policymakers to enact public health policies to prevent the disease through health education and risk factors avoidance. Screening for early disease detection in high-risk populations could improve overall outcome.

Keywords

Squamous cell cancer Esophageal cancer Epidemiology Pathogenesis Tobacco Alcohol 

References

  1. 1.
    Zeng H, Zheng R, Guo Y, et al. Cancer survival in China, 2003–2005: a population-based study. Int J Cancer. 2015;136(8):1921–30.  https://doi.org/10.1002/ijc.29227.CrossRefPubMedGoogle Scholar
  2. 2.
    Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66(1):7–30.  https://doi.org/10.3322/caac.21332.CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    De Angelis R, Sant M, Coleman MP, et al. Cancer survival in Europe 1999-2007 by country and age: results of EUROCARE--5-a population-based study. Lancet Oncol. 2014;15(1):23–34.  https://doi.org/10.1016/S1470-2045(13)70546-1.CrossRefPubMedGoogle Scholar
  4. 4.
    White RE, Parker RK, Fitzwater JW, et al. Stents as sole therapy for oesophageal cancer: a prospective analysis of outcomes after placement. Lancet Oncol. 2009;10(3):240–6.  https://doi.org/10.1016/S1470-2045(09)70004-X.CrossRefPubMedGoogle Scholar
  5. 5.
    Dawsey SP, Tonui S, Parker RK, et al. Esophageal cancer in young people: a case series of 109 cases and review of the literature. PLoS One. 2010;5(11):e14080.  https://doi.org/10.1371/journal.pone.0014080.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Murphy G, McCormack V, Abedi-Ardekani B, et al. International cancer seminars: a focus on esophageal squamous cell carcinoma. Ann Oncol. 2017;28(9):2086–93.  https://doi.org/10.1093/annonc/mdx279.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer. 2013;49(6):1374–403.  https://doi.org/10.1016/j.ejca.2012.12.027.CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Arnold M, Soerjomataram I, Ferlay J, et al. Global incidence of oesophageal cancer by histological subtype in 2012. Gut. 2015;64(3):381–7.  https://doi.org/10.1136/gutjnl-2014-308124.CrossRefPubMedGoogle Scholar
  9. 9.
    Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55(2):74–108.CrossRefPubMedGoogle Scholar
  10. 10.
    Chen WQ, Zheng RS, Zhang SW, et al. Report of incidence and mortality in China cancer registries, 2008. Chin J Cancer Res. 2012;24(3):171–80.  https://doi.org/10.1007/s11670-012-0171-2.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Cancer IAfRo. List of classifications by cancer sites with sufficient or limited evidence in humans; 2014. p. 1–105.Google Scholar
  12. 12.
    Bagnardi V, Rota M, Botteri E, et al. Light alcohol drinking and cancer: a meta-analysis. Ann Oncol. 2013;24(2):301–8.  https://doi.org/10.1093/annonc/mds337.CrossRefPubMedGoogle Scholar
  13. 13.
    Islami F, Fedirko V, Tramacere I, et al. Alcohol drinking and esophageal squamous cell carcinoma with focus on light-drinkers and never-smokers: a systematic review and meta-analysis. Int J Cancer. 2011;129(10):2473–84.  https://doi.org/10.1002/ijc.25885.CrossRefPubMedGoogle Scholar
  14. 14.
    Muwonge R, Ramadas K, Sankila R, et al. Role of tobacco smoking, chewing and alcohol drinking in the risk of oral cancer in Trivandrum, India: a nested case-control design using incident cancer cases. Oral Oncol. 2008;44(5):446–54.  https://doi.org/10.1016/j.oraloncology.2007.06.002.CrossRefPubMedGoogle Scholar
  15. 15.
    Prabhu A, Obi KO, Rubenstein JH. The synergistic effects of alcohol and tobacco consumption on the risk of esophageal squamous cell carcinoma: a meta-analysis. Am J Gastroenterol. 2014;109(6):822–7.  https://doi.org/10.1038/ajg.2014.71.CrossRefPubMedGoogle Scholar
  16. 16.
    Tuyns AJ. Oesophageal cancer in non-smoking drinkers and in non-drinking smokers. Int J Cancer. 1983;32(4):443–4.CrossRefPubMedGoogle Scholar
  17. 17.
    Engel LS, Chow WH, Vaughan TL, et al. Population attributable risks of esophageal and gastric cancers. J Natl Cancer Inst. 2003;95(18):1404–13.CrossRefPubMedGoogle Scholar
  18. 18.
    (IARC) IAfRoC. Attributable causes of Cancer in France in the year 2000. IARC working group reports 3. Lyon: IARC; 2007.Google Scholar
  19. 19.
    Parkin DM, Boyd L, Walker LC. 16. The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010. Br J Cancer. 2011;105(Suppl 2):S77–81.  https://doi.org/10.1038/bjc.2011.489.CrossRefPubMedPubMedCentralGoogle Scholar
  20. 20.
    Wang JB, Fan JH, Liang H, et al. Attributable causes of esophageal cancer incidence and mortality in China. PLoS One. 2012;7(8):e42281.  https://doi.org/10.1371/journal.pone.0042281.CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Gu D, Kelly TN, Wu X, et al. Mortality attributable to smoking in China. N Engl J Med. 2009;360(2):150–9.  https://doi.org/10.1056/NEJMsa0802902.CrossRefPubMedGoogle Scholar
  22. 22.
    Sampson JN, Wheeler WA, Yeager M, et al. Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types. J Natl Cancer Inst. 2015;107(12):djv279.  https://doi.org/10.1093/jnci/djv279.CrossRefPubMedPubMedCentralGoogle Scholar
  23. 23.
    Tran GD, Sun XD, Abnet CC, et al. Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China. Int J Cancer. 2005;113(3):456–63.  https://doi.org/10.1002/ijc.20616.CrossRefPubMedGoogle Scholar
  24. 24.
    Gao Y, Hu N, Han X, et al. Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China. BMC Cancer. 2009;9:269.  https://doi.org/10.1186/1471-2407-9-269.CrossRefPubMedPubMedCentralGoogle Scholar
  25. 25.
    Akbari MR, Malekzadeh R, Nasrollahzadeh D, et al. Familial risks of esophageal cancer among the Turkmen population of the Caspian littoral of Iran. Int J Cancer. 2006;119(5):1047–51.  https://doi.org/10.1002/ijc.21906.CrossRefPubMedGoogle Scholar
  26. 26.
    Li XY, Su M, Huang HH, et al. mtDNA evidence: genetic background associated with related populations at high risk for esophageal cancer between Chaoshan and Taihang Mountain areas in China. Genomics. 2007;90(4):474–81.  https://doi.org/10.1016/j.ygeno.2007.06.006.CrossRefPubMedGoogle Scholar
  27. 27.
    Blaydon DC, Etheridge SL, Risk JM, et al. RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome. Am J Hum Genet. 2012;90(2):340–6.  https://doi.org/10.1016/j.ajhg.2011.12.008.CrossRefPubMedPubMedCentralGoogle Scholar
  28. 28.
    Brooks PJ, Enoch MA, Goldman D, et al. The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption. PLoS Med. 2009;6(3):e50.  https://doi.org/10.1371/journal.pmed.1000050.CrossRefPubMedGoogle Scholar
  29. 29.
    Baan R, Straif K, Grosse Y, et al. Carcinogenicity of alcoholic beverages. Lancet Oncol. 2007;8(4):292–3.CrossRefPubMedGoogle Scholar
  30. 30.
    Yokoyama A, Kumagai Y, Yokoyama T, et al. Health risk appraisal models for mass screening for esophageal and pharyngeal cancer: an endoscopic follow-up study of cancer-free Japanese men. Cancer Epidemiol Biomark Prev. 2009;18(2):651–5.  https://doi.org/10.1158/1055-9965.EPI-08-0758.CrossRefGoogle Scholar
  31. 31.
    Research. WCRFAIfC. Continuous update project report: diet, nutrition, physical activity and oesophageal cancer. Washington: AICR; 2016.Google Scholar
  32. 32.
    Li WQ, Park Y, Wu JW, et al. Index-based dietary patterns and risk of esophageal and gastric cancer in a large cohort study. Clin Gastroenterol Hepatol. 2013;11(9):1130–36 e2.  https://doi.org/10.1016/j.cgh.2013.03.023.CrossRefPubMedPubMedCentralGoogle Scholar
  33. 33.
    Cheng KK, Day NE, Duffy SW, et al. Pickled vegetables in the aetiology of oesophageal cancer in Hong Kong Chinese. Lancet. 1992;339(8805):1314–8.CrossRefPubMedGoogle Scholar
  34. 34.
    Yang CS. Research on esophageal cancer in China: a review. Cancer Res. 1980;40(8 Pt 1):2633–44.PubMedGoogle Scholar
  35. 35.
    Vingeliene S, Chan DS, Aune D, et al. An update of the WCRF/AICR systematic literature review on esophageal and gastric cancers and citrus fruits intake. Cancer Causes Control. 2016;27(7):837–51.  https://doi.org/10.1007/s10552-016-0755-0.CrossRefPubMedPubMedCentralGoogle Scholar
  36. 36.
    Liu J, Wang J, Leng Y, et al. Intake of fruit and vegetables and risk of esophageal squamous cell carcinoma: a meta-analysis of observational studies. Int J Cancer. 2013;133(2):473–85.  https://doi.org/10.1002/ijc.28024.CrossRefPubMedGoogle Scholar
  37. 37.
    Qiao YL, Dawsey SM, Kamangar F, et al. Total and cancer mortality after supplementation with vitamins and minerals: follow-up of the Linxian General Population Nutrition Intervention Trial. J Natl Cancer Inst. 2009;101(7):507–18.  https://doi.org/10.1093/jnci/djp037.CrossRefPubMedPubMedCentralGoogle Scholar
  38. 38.
    Choi Y, Song S, Song Y, et al. Consumption of red and processed meat and esophageal cancer risk: meta-analysis. World J Gastroenterol. 2013;19(7):1020–9.  https://doi.org/10.3748/wjg.v19.i7.1020.CrossRefPubMedPubMedCentralGoogle Scholar
  39. 39.
    Andrici J, Eslick GD. Mate consumption and the risk of esophageal squamous cell carcinoma: a meta-analysis. Dis Esophagus. 2013;26(8):807–16.  https://doi.org/10.1111/j.1442-2050.2012.01393.x.CrossRefPubMedGoogle Scholar
  40. 40.
    Lubin JH, De Stefani E, Abnet CC, et al. Mate drinking and esophageal squamous cell carcinoma in South America: pooled results from two large multicenter case-control studies. Cancer Epidemiol Biomark Prev. 2014;23(1):107–16.  https://doi.org/10.1158/1055-9965.EPI-13-0796.CrossRefGoogle Scholar
  41. 41.
    Ke L. Mortality and incidence trends from esophagus cancer in selected geographic areas of China circa 1970-90. Int J Cancer. 2002;102(3):271–4.  https://doi.org/10.1002/ijc.10706.CrossRefPubMedGoogle Scholar
  42. 42.
    Andrici J, Eslick GD. Hot food and beverage consumption and the risk of esophageal cancer: a meta-analysis. Am J Prev Med. 2015;49(6):952–60.  https://doi.org/10.1016/j.amepre.2015.07.023.CrossRefPubMedGoogle Scholar
  43. 43.
    Wu M, Liu AM, Kampman E, et al. Green tea drinking, high tea temperature and esophageal cancer in high- and low-risk areas of Jiangsu Province, China: a population-based case-control study. Int J Cancer. 2009;124(8):1907–13.  https://doi.org/10.1002/ijc.24142.CrossRefPubMedGoogle Scholar
  44. 44.
    He D, Zhang DK, Lam KY, et al. Prevalence of HPV infection in esophageal squamous cell carcinoma in Chinese patients and its relationship to the p53 gene mutation. Int J Cancer. 1997;72(6):959–64.CrossRefPubMedGoogle Scholar
  45. 45.
    Petrick JL, Wyss AB, Butler AM, et al. Prevalence of human papillomavirus among oesophageal squamous cell carcinoma cases: systematic review and meta-analysis. Br J Cancer. 2014;110(9):2369–77.  https://doi.org/10.1038/bjc.2014.96.CrossRefPubMedPubMedCentralGoogle Scholar
  46. 46.
    Koshiol J, Wei WQ, Kreimer AR, et al. No role for human papillomavirus in esophageal squamous cell carcinoma in China. Int J Cancer. 2010;127(1):93–100.  https://doi.org/10.1002/ijc.25023.CrossRefPubMedPubMedCentralGoogle Scholar
  47. 47.
    Sitas F, Egger S, Urban MI, et al. InterSCOPE study: associations between esophageal squamous cell carcinoma and human papillomavirus serological markers. J Natl Cancer Inst. 2012;104(2):147–58.  https://doi.org/10.1093/jnci/djr499.CrossRefPubMedPubMedCentralGoogle Scholar
  48. 48.
    Halec G, Schmitt M, Egger S, et al. Mucosal alpha-papillomaviruses are not associated with esophageal squamous cell carcinomas: lack of mechanistic evidence from South Africa, China and Iran and from a world-wide meta-analysis. Int J Cancer. 2016;139(1):85–98.  https://doi.org/10.1002/ijc.29911.CrossRefPubMedPubMedCentralGoogle Scholar
  49. 49.
    Poon RT, Law SY, Chu KM, et al. Multiple primary cancers in esophageal squamous cell carcinoma: incidence and implications. Ann Thorac Surg. 1998;65(6):1529–34.CrossRefPubMedGoogle Scholar
  50. 50.
    Shaha AR, Hoover EL, Mitrani M, et al. Synchronicity, multicentricity, and metachronicity of head and neck cancer. Head Neck Surg. 1988;10(4):225–8.CrossRefPubMedGoogle Scholar
  51. 51.
    Ribeiro U Jr, Posner MC, Safatle-Ribeiro AV, et al. Risk factors for squamous cell carcinoma of the oesophagus. Br J Surg. 1996;83(9):1174–85.CrossRefPubMedGoogle Scholar
  52. 52.
    Chen X, Yuan Z, Lu M, et al. Poor oral health is associated with an increased risk of esophageal squamous cell carcinoma - a population-based case-control study in China. Int J Cancer. 2017;140(3):626–35.  https://doi.org/10.1002/ijc.30484.CrossRefPubMedGoogle Scholar
  53. 53.
    Guha N, Boffetta P, Wunsch Filho V, et al. Oral health and risk of squamous cell carcinoma of the head and neck and esophagus: results of two multicentric case-control studies. Am J Epidemiol. 2007;166(10):1159–73.  https://doi.org/10.1093/aje/kwm193.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Esophageal and Upper Gastrointestinal Surgery, Department of SurgeryThe University of Hong Kong, Queen Mary HospitalHong KongChina

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