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Molecular Mechanism of Self-Organization in Biological Systems

  • Tara Karimi
Chapter

Abstract

Self-organization is the autonomous formation of complex structures from units of less complexity by local internal interactions. As a precise model of self-organization in nature, embryonic organogenesis is a process where different tissues and organs form in a growing embryo by the autonomous assembling of cells together.

Embryonic self-organization, which occurs at different levels of complexity from nano to macro levels in biological systems, is a highly efficient autonomous process. Self-organization is like robotics without wires and motors. It means the manufacturing program is embedded in materials themselves.

When we look at the manufacturing and construction process through different industries, there are major efficiency issues in energy consumption and labor work compared to autonomous formation and assembling of system’s parts during self-organization.

In this chapter, we will discuss the regulatory mechanisms behind embryonic organogenesis through the information storage in biomolecules. In addition, specifically, we discuss on molecular regulation of both differentiation and morphogenesis and their application in regenerative medicine. Deep understanding of regulatory mechanisms of self-organization can open new avenues in designing next generation smart, self-organizing materials and systems for both industrial and biomedical applications.

Keywords

Self-organization Embryonic organogenesis Morphogenesis Protein folding Autonomous manufacturing Programmable materials 3D and 4D printing Cognitive chemistry 

References

  1. 1.
    Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P (2008) Molecular biology of the cell, 5th edn. Garland Science Taylor and Francis Group, New YorkGoogle Scholar
  2. 2.
    Christian JL (2012) Morphogen gradients in development from form to function. Wiley Interdiscip Rev Dev Biol 1(1):3–15CrossRefPubMedGoogle Scholar
  3. 3.
    Deglincerti A et al (2016) Self-organization of spatial patterning in human embryonic stem cells. Curr Top Devel Biol 116:99–113CrossRefGoogle Scholar
  4. 4.
    Fritze O et al (2003) Role of conserved NP xxY(X) 5,6,F motif in the rhodopsin ground state and during activation. PNS 100(5):2290–2295CrossRefGoogle Scholar
  5. 5.
    Gilbert S (2010) Developmental biology, 9th edn. Sinauer Associates Inc, Sunderland, EnglandGoogle Scholar
  6. 6.
    Greggio C et al (2015) In vitro- produced pancreas organogenesis models in three dimensions; self-organization from few stem cells or progenitors. Stem Cells 33(1):8–14CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Huang G et al (2015) Molecular basis of embryonic stem cell self-renewal: from signaling pathway to pluripotency. Cell Mol Life Sci 72(9):1741–1757Google Scholar
  8. 8.
    Kauffman SA (1993) The origins of order: self-organization and selection in evolution. Oxford University Press, New YorkGoogle Scholar
  9. 9.
    Kauffman SA (1995) At home in the universe: the search for the laws of self-organization and complexity. Oxford University Press, New YorkGoogle Scholar
  10. 10.
    Kauffman SA (2000) Investigations. Oxford University Press, New YorkGoogle Scholar
  11. 11.
    Kwan CW et al (2016) Functional evolution of a morphogenetic gradient. eLife 5:1–12CrossRefGoogle Scholar
  12. 12.
    Lauschke VM et al (2013) Scaling of embryonic patterning based on phase gradient encoding. Nature Letter 493:101–105CrossRefGoogle Scholar
  13. 13.
    Lee SS, Shibata T (2015) Self-organization and advective transport in the cell polarity formation for asymmetric cell division. J Theor Biol 382:1–14CrossRefGoogle Scholar
  14. 14.
    Lewis EB (1978) A gene complex controlling segmentation in Drosophila. Nature 276(7):565–570CrossRefPubMedGoogle Scholar
  15. 15.
    Mark F, et al (2009) Cellular signal processing; an introduction to the molecular mechanism of signal transduction. Garland Science Tylor and Francis Group, New York, USAGoogle Scholar
  16. 16.
    Marsh JA, Forman-Kay JD (2010) Sequence determinants of compaction in intrinsically disordered proteins. Biophys J 98:2383–2390CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Moret MA (2011) A self-organized critical model for protein folding. Physica A 390:3055–3059CrossRefGoogle Scholar
  18. 18.
    Nelson DL, Cox MM (2017) Lehninger principles of biochemistry, 7th edn. Freeman, W H& Company, New YorkGoogle Scholar
  19. 19.
    Nepusz T, Vicsek T (2013) Hierarchical self-organization of non-cooperating individuals. PLoS One 8(12):1–9CrossRefGoogle Scholar
  20. 20.
    Northrop B, Zheng Y, Chi K, Stang P (2009) Self-organization in coordination-driven self-assembly. Acc Chem Res 42(10):1554–1563CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Oron E, Ivanova N (2012) Cell fate regulation in early mammalian development. Phys Biol 9:1–19CrossRefGoogle Scholar
  22. 22.
    Partiff DE, Shen MM (2014) From blastocyst to gastrula: gene regulatory networks of embryonic stem cells and early mouse embryogenesis. Philos Trans R Soc Lond B Biol Sci 369(1657):1–12Google Scholar
  23. 23.
    Rodwell VW, Bender D, Botham K, Kennelly P, Weil PA (2015) Harpers illustrated biochemistry, 30th edn. The McGraw Hill Education, New York/LondonGoogle Scholar
  24. 24.
    Rossant J, Tam PP (2009) Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse. Development 136(5):701–713Google Scholar
  25. 25.
    Sanger A, Briscoe J (2017) Morphogen interpretation, concentration, time, competence, and signaling dynamics. Dev Biol 6:1–19CrossRefGoogle Scholar
  26. 26.
    Sasai Y, Eiraku M, Suga H (2012) Invitro organogenesis in three dimensions: self-organizing stem cells. Development 139:4111–4121CrossRefPubMedGoogle Scholar
  27. 27.
    Shahbazi MN et al (2016) Self-organization of the human embryo in the absence of maternal tissues. Nat Cell Biol 18(6):700–708CrossRefPubMedPubMedCentralGoogle Scholar
  28. 28.
    Simister PC et al (2011) Self-organization and regulation of intrinsically disordered proteins with folded N-termini. PLoS Biol 9(2):1–4CrossRefGoogle Scholar
  29. 29.
    Turing AM (1952) The chemical basis of morphogenesis. Philosophical Transactions of the Royal Society of London Series B Biological Sciences 237(641):37–72CrossRefGoogle Scholar
  30. 30.
    Wartlick O et al (2014) Growth control by a moving morphogen gradient during Drosophila eye development. Biol Develop 141:1884–1893Google Scholar
  31. 31.
    Zeeuo T, Weijers D (2016) Plants organogenesis: rules of order. Curr Biol 26:157–179CrossRefGoogle Scholar
  32. 32.
    Zernicka-Goetz M (2002) Patterning of the embryo: the first spatial decisions in the life of a mouse. Development 129(4):815–829.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Tara Karimi
    • 1
  1. 1.Tulane Medical CenterTulane UniversityNew OrleansUSA

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