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Channellopathies: New ECG Criteria for Risk Stratification

  • Paolo Compagnucci
  • Simone D’Agostino
  • Alessia Quaranta
  • Giulio Spinucci
Chapter

Abstract

Cardiac channellopathies—such as long QT syndrome (LQTS), Brugada syndrome (BrS), and short QT syndrome (SQTS)—are genetic disorders secondary to different ion channel mutations predisposing to ventricular tachyarrhythmias and sudden cardiac death (SCD). Arrhythmic risk is particularly elevated in symptomatic patients, and nonfatal events (syncope, documented TV, and aborted cardiac arrest) remain the strongest predictor of SCD and are an indication to ICD implantation.

Some marker and specific finding on the basal electrocardiogram (such as QT length and dispersion in LQTS or the association with atrial fibrillation and conduction delays in Brugada syndrome) can help in estimating the specific arrhythmic risk.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Paolo Compagnucci
    • 1
  • Simone D’Agostino
    • 1
  • Alessia Quaranta
    • 1
  • Giulio Spinucci
    • 1
  1. 1.Clinica di Cardiologia e AritmologiaOspedali Riuniti di AnconaAnconaItaly

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