Evidence-Based Principles of Antibiotic Therapy
Oh, for the days when I could just write a prescription for penicillin and know that it would be effective for my patient! Those days are over. Now, I have to worry about whether the antibiotic will cover the usual organisms in the infection; if there are highly antibiotic-resistant bacteria present; if my prescription will select for resistant organisms in the patient, or her family, or his community; if the patient will have a toxic or allergic reaction; or if it will interact with one of the many other drugs the patient is taking. What if my patient can’t afford the antibiotic or doesn’t take it as prescribed? How long will he really take the antibiotic for? Just until he feels better? Should I be prescribing this antibiotic at all?
Modern antibiotic therapy for odontogenic infections has become quite complex. This chapter will provide the available evidence that answers the above questions as well as is possible with our current knowledge. It lists the ten principles of the modern use of antibiotics and provides the evidence supporting those principles. Some of these principles apply to the issue of antibiotic selection and others to proper administration of antibiotics.
KeywordsOdontogenic infection Antibiotic therapy Antibiotic resistance Antibiotic drug interactions Antibiotic toxicities Antibiotic cost Prophylactic antibiotics
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