Pulmonary Vascular Disease: Specific Evaluation and Timing for Listing Eligible Patients to Receive Lung Transplantation and Management of the Pre-lung Transplant Patient

  • Alison S. WitkinEmail author
  • Richard N. Channick


Pulmonary arterial hypertension is characterized by progressive vasculopathy in the pulmonary arterial bed leading to right ventricular dysfunction and failure. Despite significant advances in medical therapy over the last several decades, lung transplantation remains a necessary treatment option for patients with severe and refractory disease. This chapter discusses the role of lung transplantation in the management of pulmonary hypertension as well as transplant-specific considerations, including the use of single versus dual lung transplant and the diminishing role of combined heart and lung transplantation.


Pulmonary hypertension Pulmonary arterial hypertension Lung transplantation Heart transplantation Chronic thromboembolic pulmonary hypertension Pulmonary veno-occlusive disease Pulmonary capillary hemangiomatosis 



Six minute walk distance


Attributable pulmonary hypertension


Cystic fibrosis


Congenital heart disease


Chronic obstructive pulmonary disease


Double-lung transplant


Extracorporeal membrane oxygenation


Food and Drug Administration


Idiopathic pulmonary fibrosis


Lung allocation score


Lung transplant


Heart/lung transplant


Interstitial lung disease


Idiopathic pulmonary arterial hypertension


Mean pulmonary artery pressure


New York Heart Association


Pulmonary arterial hypertension


Pulmonary artery systolic pressure


Pulmonary capillary hemangiomatosis


Pulmonary capillary wedge pressure


Pulmonary hypertension


Persistent pulmonary hypertension of the newborn


Pulmonary thromboendarterectomy


Pulmonary veno-occlusive disease


Pulmonary vascular resistance


Right heart catheterization


Secondary pulmonary hypertension


Transthoracic echocardiogram




World Health Organization


Woods units


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Copyright information

© The Author(s) 2018

Authors and Affiliations

  1. 1.Division of Pulmonary and Critical Care Medicine, Department of MedicineMassachusetts General HospitalBostonUSA

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