Modulation of the Core Synaptic Network in Extinction: The Role of Brain-Derived Neurotrophic Factor

  • Maxwell Bennett
  • Jim Lagopoulos


Microinfusion of BDNF or its neutralizing antibody into the basolateral amygdala (BLA), infralimbic cortex (IL) or hippocampus (HPC) points to synapses in the IL as requiring this neurotrophin for the relatively long-duration long-term potentiation (lLTP) supporting fear extinction. During fear extinction the increase of BDNF in the IL follows the increase of BDNF in ventral HPC (Chhatwal et al. 2006; Peters et al. 2010). The excitability of IL neurons is enhanced by microinfusion of BDNF into the ventral HPC following fear conditioning, (Rosas-Vidal et al. 2014) suggesting that BDNF has been transported from the latter to the former (Burgos-Robles et al. 2007; Chang et al. 2010; Knapska and Maren 2009; Peters et al. 2010; Rosas-Vidal et al. 2014). This is supported by the observation that co-microinfusion of BDNF into the hippocampus together with BDNF antibody into IL blocks the BDNF-generated extinction (Peters et al. 2010). Rats that are opaque to extinction training show poor BDNF projections from the middle HPC to the IL (Peters et al. 2010).


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Maxwell Bennett
    • 1
  • Jim Lagopoulos
    • 2
  1. 1.The University of SydneyBrain and Mind CentreCamperdown NSWAustralia
  2. 2.Sunshine Coast Mind and Neuroscience Thompson InstituteUniversity of Sunshine CoastBirtinyaAustralia

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