Modulation of the Core Neural Network in Stress: The Role of Endocannabinoids and LTD

  • Maxwell Bennett
  • Jim Lagopoulos


Both clinical and animal studies point to the importance of endocannabiniods in extinction (Sect. 5.1.1). Single nucleotide polymorphisms in pathways controlling endocannabinoids have profound effects on the level of these in the amygdala in response to stress (Sect. 5.1.2). The core network controlling the responses to stress in the amygdala is of major interest in this review, particularly in the context of extinction, for which we now have considerable insights from animal studies (Sect. 5.1.3). These, together with clinical observations, indicate that endocannabinoids and BDNF may act together in a feedback pathway that sustains the level of the former and therefore the extent and duration of extinction (Sect. 5.1.4).


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Maxwell Bennett
    • 1
  • Jim Lagopoulos
    • 2
  1. 1.The University of SydneyBrain and Mind CentreCamperdown NSWAustralia
  2. 2.Sunshine Coast Mind and Neuroscience Thompson InstituteUniversity of Sunshine CoastBirtinyaAustralia

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