Toward Noninvasive Drug Injection via Control of Laser-Induced Breakdown in Liquid
A microjet with a maximum speed of 300 m/s and a diameter of 150 μm is ejected from a nozzle by the pulsed laser-induced bubble expansion. At every pulse of laser irradiation in the driving chamber, adverse air bubble growth has been a major issue in sustaining a uniform jet speed and overall performance of drug delivery. Here, a check valve is introduced to the drug chamber for controlling the flow dynamics inside and thus preventing ambient air from entering the nozzle. The newly designed valve in the laser-induced microjet injector proves that constant jet speed is possible regardless of the number of laser pulses, which allows the penetration of porcine skin to reach a depth well beyond 1.5–2.25 times the previously attained depths.
Authors wish to acknowledge the financial supports from SNU Brain Fusion Program 2015 and National Research Foundation under NSL Program 2014 through IOER and IAAT at Seoul National University. Many valuable discussions with Prof. Cheol-Woong Sim of College of the Fine Arts and Prof. Woo-Cheol Lee of School of Dentistry are thankfully acknowledged.
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