Intracellular Ca2+ Increase Evoked by Single Acoustic Pulses

  • A. TsukamotoEmail author
  • T. Takahashi
  • S. Tada
  • K. Nakagawa
Conference paper


Shock wave therapies require cellular responses. However, how shock waves interact with cells remains elusive. In this study, it was asked whether pressure discontinuities at wave fronts of shock waves are indispensable for evoking cellular responses. With shock wave irradiations, intracellular Ca2+ increase was evoked in endothelial cells. This cellular response was independent of pressure increment at front of shock waves. These results suggest that pressure discontinuity at wave front is not indispensable for evoking the cellular response.


  1. 1.
    T. Nishida, H. Shimokawa, K. Oi, H. Tatewaki, T. Uwatoku, K. Abe, Y. Matsumoto, N. Kajihara, M. Eto, T. Matsuda, H. Yasui, A. Takeshita, K. Sunagawa, Extracorporeal cardiac shock wave therapy markedly ameliorates ischemia-induced myocardial dysfunction in pigs in vivo. Circulation 110, 3055 (2004)CrossRefGoogle Scholar
  2. 2.
    J.B. Lansman, T.J. Hallam, T.J. Rink, Single stretch-activated ion channels in vascular endothelial cells as mechanotransducers? Nature 325, 811 (1987)CrossRefGoogle Scholar
  3. 3.
    A. Tsukamoto, Y. Hayashida, K.S. Furukawa, T. Ushida, Spatio-temporal PLC activation in parallel with intracellular Ca2+ wave propagation in mechanically stimulated single MDCK cells. Cell Calcium 47, 253 (2010)CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • A. Tsukamoto
    • 1
    Email author
  • T. Takahashi
    • 1
  • S. Tada
    • 1
  • K. Nakagawa
    • 2
  1. 1.National Defense Academy, Hashirimizu 1-10-20YokosukaJapan
  2. 2.The University of Tokyo, Hongo 7-3-1, Bunkyo-kuTokyoJapan

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