Hepatotoxicity and Hepatic Dysfunction

  • Ahmet Taner Sümbül
  • Özgür Özyılkan


Cancer is a multisystemic disease, and every patient needs detailed evaluation before building a treatment plan. In the setting of multiple therapeutic modalities, chemotherapy which consists of conventional and novel therapeutics (tyrosine kinase inhibitors, monoclonal antibodies, immunotherapies, etc.) is the most widely used one. The metabolism and clearance of these drugs are mostly dependent on a normally functioning kidney and liver. Monitoring the liver function tests during the treatment period is crucial for preventing permanent harmful and fatal outcomes.

Especially, the liver is the keystone for the metabolism (i.e., inactivation or activation) and clearance of anticancer agents which are commonly used in different types of cancers. In most cases it is impossible to distinguish the cause of liver dysfunction from cause as compared to other comorbid conditions, and this makes the clinicians job much more complicated before deciding about therapy. Assessment of liver function and uncovering of preexisting liver diseases should be the approach before starting and also during therapy for the optimal management.


Cancer Hepatic dysfunction Hepatotoxicity Conventional and targeted therapies Management 


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Ahmet Taner Sümbül
    • 1
  • Özgür Özyılkan
    • 1
  1. 1.Department of Medical OncologyBaskent University School of Medicine, Baskent Universitesi Adana Hastanesi Kisla Yerleskesi Tibbi Onkoloji BD Kazim Karabekir cadYuregirAdanaTurkey

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