You Really “Oughta” Get This

  • Mark T. Friedman
  • Kamille A. West
  • Peyman Bizargity
  • Kyle Annen
  • Jeffrey S. Jhang


A 20-year-old woman with a history of systemic lupus erythematosus and idiopathic (immune) thrombocytopenic purpura (ITP), who received intravenous Rh immune globulin (IV RhIg) 1 year ago for the treatment of ITP and has no prior history of red blood cell (RBC) transfusion or pregnancy, is found to have a hematocrit (Hct) level of 15%. The patient was referred to the emergency department by her primary care physician for stat RBC transfusion of two units. A type and screen sample along with an order for the RBCs (ethylenediaminetetraacetic acid [EDTA] anticoagulant) is submitted to the blood bank.


Autoadsorption Autoimmune hemolytic anemia Elution Idiopathic/immune thrombocytopenic purpura Immunosuppressive agents Rh immune globulin 


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Recommended Reading

  1. Leger RM. The positive direct antiglobulin test and immune-mediated hemolysis. In: Fung MK, Grossman BJ, Hillyer CD, Westhoff CM, editors. Technical manual. 18th ed. Bethesda: AABB; 2014. p. 425.Google Scholar
  2. Packman CH. The clinical pictures of autoimmune hemolytic anemia. Transfus Med Hemother. 2015;42(5):317–24.CrossRefGoogle Scholar
  3. Scaradavou A, Woo B, Woloski BMR, et al. Intravenous anti-D treatment of immune thrombocytopenic purpura: experience in 272 patients. Blood. 1997;89(8):2689–700.PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Mark T. Friedman
    • 1
  • Kamille A. West
    • 2
  • Peyman Bizargity
    • 3
  • Kyle Annen
    • 4
  • Jeffrey S. Jhang
    • 1
  1. 1.Icahn School of MedicineMount Sinai Health SystemNew YorkUSA
  2. 2.Department of Transfusion MedicineNational Institutes of Health Clinical CenterBethesdaUSA
  3. 3.Department of Molecular & Human GeneticsBaylor College of MedicineHoustonUSA
  4. 4.Department of PathologyChildren’s Hospital ColoradoAuroraUSA

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