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Do the Math!

  • Mark T. Friedman
  • Kamille A. West
  • Peyman Bizargity
  • Kyle Annen
  • Jeffrey S. Jhang
Chapter

Abstract

A 72-year-old man is admitted to the hospital with a presumptive diagnosis of acute myeloid leukemia. He is scheduled for bone marrow biopsy but has a platelet count of 7 K/μL (7000/μL). A type and screen sample (ethylenediaminetetraacetic acid [EDTA] anticoagulant) is submitted to the blood bank along with a request for two units of apheresis platelets.

Keywords

Corrected count increment Crossmatched platelets Flow cytometry HLA-matched platelets Human platelet antigen Modified antigen capture enzyme-linked immunosorbent assay/MACE Panel reactive antibody Platelet refractoriness Solid-phase red cell adherence/SPRCA 

References

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    The Trial to Reduce Alloimmunization to Platelets Study Group. Leukocyte reduction and ultraviolet B irradiation of platelets to prevent alloimmunization and refractoriness to platelet transfusions. N Engl J Med. 1997;337:1861–70.CrossRefGoogle Scholar
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    Kopko PM, Warner P, Kresie L, Pancoska C. Methods for the selection of platelet products for alloimmune-refractory patients. Transfusion. 2015;55(2):235–44.CrossRefPubMedGoogle Scholar
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    Juskewitch JE, Norgan AP, De Goey SR, Duellman PM, Wakefield LL, Gandhi MJ, et al. How do I…manage the platelet transfusion-refractory patient? Transfusion. 2017;57(12):2828–35.CrossRefPubMedGoogle Scholar

Recommended Reading

  1. Curtis BR. Platelet and granulocyte antigens and antibodies. In: Fung MK, Grossman BJ, Hillyer CD, Westhoff CM, editors. Technical manual. 18th ed. Bethesda: AABB; 2014. p. 458–61.Google Scholar
  2. Juskewitch JE, Norgan AP, De Goey SR, Duellman PM, Wakefield LL, Gandhi MJ, et al. How do I…manage the platelet transfusion-refractory patient? Transfusion. 2017;57(12):2828–35.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Mark T. Friedman
    • 1
  • Kamille A. West
    • 2
  • Peyman Bizargity
    • 3
  • Kyle Annen
    • 4
  • Jeffrey S. Jhang
    • 1
  1. 1.Icahn School of MedicineMount Sinai Health SystemNew YorkUSA
  2. 2.Department of Transfusion MedicineNational Institutes of Health Clinical CenterBethesdaUSA
  3. 3.Department of Molecular & Human GeneticsBaylor College of MedicineHoustonUSA
  4. 4.Department of PathologyChildren’s Hospital ColoradoAuroraUSA

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