Advertisement

Baby Fate

  • Mark T. Friedman
  • Kamille A. West
  • Peyman Bizargity
  • Kyle Annen
  • Jeffrey S. Jhang
Chapter

Abstract

A 24-year-old woman, gravida 1, para 0 (G1P0), at 38 weeks of gestation presents to labor and delivery for spontaneous rupture of membranes. Her pregnancy was uneventful. A baby girl is delivered 13 h later by normal spontaneous vaginal delivery. The baby’s Apgar scores are 8 and 9 at 1 and 5 min, respectively. Shortly after being taken to the nursery, the nurse notices that the baby has diffuse petechiae on the face, scalp, and shoulders. The mother’s hemoglobin is 12.8 g/dL, and the platelet count is 182 K/μL. Meanwhile, the neonatal hemoglobin is 19.8 g/dL, and the platelet count is 32 K/μL. Samples for both the mother and the baby (cord blood sample) (ethylenediaminetetraacetic acid [EDTA] anticoagulant) are submitted to the blood bank.

Keywords

Anti-HPA-1a Fetal and neonatal thrombocytopenia/FNAIT Modified antigen-capture enzyme-linked immunosorbent assay/MACE Monoclonal antibody immobilization of platelet antigens/MAIPA Washed platelets 

References

  1. 1.
    Epinoza JP, Caradeux J, Norwitz ER, Illanes SE. Fetal and neonatal alloimmune thrombocytopenia. Rev Obstet Gynecol. 2013;6(1):e15–21.Google Scholar
  2. 2.
    Peterson JA, McFarland JG, Curtis BR, Aster RH. Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management. Br J Haematol. 2013;161(1):3–14.CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Davoren A, Curtis BR, Aster RH, McFarland JG. Human platelet antigen-specific alloantibodies implicated in 1162 cases of neonatal alloimmune thrombocytopenia. Transfusion. 2004;44:1220–5.CrossRefPubMedGoogle Scholar

Recommended Reading

  1. Holzhauer S, Zieger B. Diagnosis and management of neonatal thrombocytopenia. Semin Neonatal Med. 2011;16(6):305–10.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Mark T. Friedman
    • 1
  • Kamille A. West
    • 2
  • Peyman Bizargity
    • 3
  • Kyle Annen
    • 4
  • Jeffrey S. Jhang
    • 1
  1. 1.Icahn School of MedicineMount Sinai Health SystemNew YorkUSA
  2. 2.Department of Transfusion MedicineNational Institutes of Health Clinical CenterBethesdaUSA
  3. 3.Department of Molecular & Human GeneticsBaylor College of MedicineHoustonUSA
  4. 4.Department of PathologyChildren’s Hospital ColoradoAuroraUSA

Personalised recommendations