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All Washed Up

  • Mark T. Friedman
  • Kamille A. West
  • Peyman Bizargity
  • Kyle Annen
  • Jeffrey S. Jhang
Chapter

Abstract

A 22-year-old man with a history of homozygous factor (F)V deficiency (Owren’s disease) is admitted for an elective right knee arthroscopy. Coagulation laboratory studies show prothrombin time (PT) 18.6 s and activated partial thromboplastin time (aPTT) 55.1 s. A type and screen (ethylenediaminetetraacetic acid [EDTA] anticoagulant) sample is submitted to the blood bank along with a request for three units of fresh frozen plasma (FFP) for preoperative transfusion.

Keywords

Anaphylactic transfusion reaction Factor V deficiency Haptoglobin deficiency IgA deficiency Platelet additive solution Solvent/detergent plasma Washed red blood cells 

References

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Recommended Reading

  1. Sandler SG, Eder AF, Goldman M, Winters JL. The entity of immunoglobulin A-related anaphylactic transfusion reactions is not evidence based. Transfusion. 2015;55(1):199–204.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Mark T. Friedman
    • 1
  • Kamille A. West
    • 2
  • Peyman Bizargity
    • 3
  • Kyle Annen
    • 4
  • Jeffrey S. Jhang
    • 1
  1. 1.Icahn School of MedicineMount Sinai Health SystemNew YorkUSA
  2. 2.Department of Transfusion MedicineNational Institutes of Health Clinical CenterBethesdaUSA
  3. 3.Department of Molecular & Human GeneticsBaylor College of MedicineHoustonUSA
  4. 4.Department of PathologyChildren’s Hospital ColoradoAuroraUSA

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