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Mix and Match

  • Mark T. Friedman
  • Kamille A. West
  • Peyman Bizargity
  • Kyle Annen
  • Jeffrey S. Jhang
Chapter

Abstract

A 50-year-old woman with acute myeloid leukemia (AML) receives a hematopoietic stem cell transplant (HSCT) from a human leukocyte antigen (HLA)-matched (10/10 antigens) related donor (peripheral blood stem cells [PBSC] collected via apheresis with stimulation by granulocyte colony-stimulating factor [G-CSF] and containing at least 5 × 106 CD34+ cells/kg) post-induction chemotherapy and myeloablative conditioning. The patient and donor ABO/Rh types and antibody screens are shown below (ethylenediaminetetraacetic acid [EDTA] anticoagulant samples).

Keywords

Graft-versus-host disease/GVHD HLA matching Hematopoietic stem cell transplant Major incompatibility Marrow stem cells Minor incompatibility Passenger lymphocyte syndrome Peripheral blood stem cells Pure red cell aplasia Umbilical cord blood stem cells 

References

  1. 1.
    Daniel-Johnson J, Schwartz J. How do I approach ABO-incompatible hematopoietic progenitor cell transplantation? Transfusion. 2011;51(6):1143–9.CrossRefGoogle Scholar
  2. 2.
    Schwartz J, Padmanbhan A, Aqui N, Balogun RA, Connelly-Smith L, Delaney M, et al. Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the writing committee of the American Society of Apheresis: the seventh special issue. J Clin Apher. 2016;31:223.Google Scholar
  3. 3.
    Butler MG, Menitove JE. Umbilical cord blood banking: an update. J Assist Reprod Genet. 2011;28(8):669–76.CrossRefGoogle Scholar
  4. 4.
    Anasetti C, Logan BR, Lee SJ, Waller EK, Weisdorf EJ, Wingard JR, et al. Peripheral-blood stem cells versus bone marrow from unrelated donors. N Engl J Med. 2012;367:1487–96.CrossRefGoogle Scholar

Recommended Reading

  1. Daniel-Johnson J, Schwartz J. How do I approach ABO-incompatible hematopoietic progenitor cell transplantation? Transfusion. 2011;51(6):1143–9.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Mark T. Friedman
    • 1
  • Kamille A. West
    • 2
  • Peyman Bizargity
    • 3
  • Kyle Annen
    • 4
  • Jeffrey S. Jhang
    • 1
  1. 1.Icahn School of MedicineMount Sinai Health SystemNew YorkUSA
  2. 2.Department of Transfusion MedicineNational Institutes of Health Clinical CenterBethesdaUSA
  3. 3.Department of Molecular & Human GeneticsBaylor College of MedicineHoustonUSA
  4. 4.Department of PathologyChildren’s Hospital ColoradoAuroraUSA

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