Polly Wants a Cracker!
A 3-year-old girl is admitted to the emergency department with fever of 101.6°F accompanied by poor feeding over the prior 3 days and a persistent cough with dyspnea. Chest x-ray reveals left lower lobe pneumonia, and blood cultures are positive for Streptococcus pneumoniae. The child was born prematurely at 34 weeks by vaginal delivery and weighed 2.5 kg (current weight 12.4 kg). Laboratory values are as follows: white blood cells (WBC) 20.0 K/μL, hemoglobin (Hgb) 7.2 g/dL, hematocrit (Hct) 24%, platelet count 62 K/μL, lactate dehydrogenase (LDH) 800 U/L, prothrombin time (PT) 17.2 s, activated partial thromboplastin time (aPTT) 48.5 s, total bilirubin 5.0 mg/dL, and creatinine 4.2 mg/dL. An ethylenediaminetetraacetic acid (EDTA) anticoagulant sample is submitted to the blood bank for type and screen.
KeywordsADAMTS13 Eculizumab Hemolytic uremic syndrome/HUS Lectins Pneumococcal pneumonia Polyagglutination Shiga toxin E. coli Soliris T-activation Thrombotic thrombocytopenic purpura/TTP Von Willebrand factor
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