I Can’t Stop the Hemolysis!

  • Mark T. Friedman
  • Kamille A. West
  • Peyman Bizargity
  • Kyle Annen
  • Jeffrey S. Jhang


A 27-year-old woman with a history of sickle cell disease is admitted with pain crisis (pain in extremities and back) and possible sepsis. The patient, who has a history of anti-Fya and anti-S alloantibodies, has had several admissions to the hospital for pain crisis over the past 5 years. She was transfused two units of red blood cells (RBCs) 1 year ago and received RBC exchange transfusion (six units) for acute chest syndrome 2 years ago; all RBCs were matched by extended phenotype (C-, E-, K-negative) as per the blood bank’s policy for sickle cell patients. A type and screen sample (ethylenediaminetetraacetic acid, EDTA anticoagulant) is submitted to the blood bank.


Anti-Fya antibody Anti-S antibody Duffy blood group Evanescence Hyperhemolysis syndrome MNS blood group S antigen 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Mark T. Friedman
    • 1
  • Kamille A. West
    • 2
  • Peyman Bizargity
    • 3
  • Kyle Annen
    • 4
  • Jeffrey S. Jhang
    • 1
  1. 1.Icahn School of MedicineMount Sinai Health SystemNew YorkUSA
  2. 2.Department of Transfusion MedicineNational Institutes of Health Clinical CenterBethesdaUSA
  3. 3.Department of Molecular & Human GeneticsBaylor College of MedicineHoustonUSA
  4. 4.Department of PathologyChildren’s Hospital ColoradoAuroraUSA

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