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The Transfusion Reaction

  • Mark T. Friedman
  • Kamille A. West
  • Peyman Bizargity
  • Kyle Annen
  • Jeffrey S. Jhang
Chapter

Abstract

A 38-year-old man who underwent craniotomy surgery 2 months ago presents for outpatient red blood cell (RBC) transfusion of two units for symptomatic anemia and hemoglobin (Hgb) level of 7.4 g/dL. The patient had received multiple RBC transfusions during the craniotomy surgery and postoperatively in recovery; all of the RBC units were issued by immediate-spin (IS) crossmatch. A type and screen sample (ethylenediaminetetraacetic acid [EDTA] anticoagulant) is submitted to the blood bank along with a request for the two units of RBCs.

Keywords

Anti-Dia antibody Anti-Goa antibody Delayed hemolytic transfusion reaction Diego blood group system Febrile non-hemolytic transfusion reaction Septic transfusion reaction Transfusion reaction Transfusion-associated graft-versus-host disease/GVHD 

References

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    Larson PJ, Lukas MB, Friedman DF, Manno CS. Delayed hemolytic transfusion reaction due to anti-Goa, an antibody against the low-prevalence Gonzales antigen. Am J Hematol. 1996;53(4):248–50.CrossRefPubMedGoogle Scholar
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    Leschek E, Pearlman SA, Boudreaux I, Meek R. Severe hemolytic disease of the newborn caused by anti-Gonzales antibody. Am J Perinatol. 1993;10(5):362–4.CrossRefPubMedGoogle Scholar

Recommended Reading

  1. Klein HG, Anstee DJ. Haemolytic transfusion reactions. In: Klein HG, Anstee DJ, editors. Mollison’s blood transfusion in clinical medicine. 12th ed. West Sussex: Wiley; 2014. p. 477–82.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Mark T. Friedman
    • 1
  • Kamille A. West
    • 2
  • Peyman Bizargity
    • 3
  • Kyle Annen
    • 4
  • Jeffrey S. Jhang
    • 1
  1. 1.Icahn School of MedicineMount Sinai Health SystemNew YorkUSA
  2. 2.Department of Transfusion MedicineNational Institutes of Health Clinical CenterBethesdaUSA
  3. 3.Department of Molecular & Human GeneticsBaylor College of MedicineHoustonUSA
  4. 4.Department of PathologyChildren’s Hospital ColoradoAuroraUSA

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