Endocrine-Disrupting Chemicals and Female Fertility

  • Ronit Machtinger


Exposure to environmental toxins as BPA may impair female fertility as it mimics estradiol. In vitro studies both in animal and human models and in vivo animal studies have shown alterations in oocyte meiosis, steroidogenesis, blastocyst formation, and implantation. Although limited by short exposure time, most of these negative effects in vitro were shown in much higher concentrations than human are exposed to. While early clinical studies have linked exposure to BPA with adverse outcomes in patients undergoing IVF, a recent larger study was not consistent and did not find negative associations between urinary BPA concentrations and fertilization rates, implantation, clinical pregnancy, or live birth rates among a large cohort of women undergoing IVF. This chapter reviews the current literature regarding BPA and female fertility.


Endocrine-disrupting chemicals Female fertility Bisphenol A Meiosis Steroidogenesis Implantation IVF outcome 


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Obstetrics, Gynecology, and Reproductive BiologySheba Medical Center, Sackler School of MedicineRamat GanIsrael

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