Heat Shock Proteins in Oxidative and Nitrosative Stress

  • Kattaia Asmaa A. A. A. 
  • Abd El-Baset Samia A. 
  • Eman M. Mohamed
Part of the Heat Shock Proteins book series (HESP, volume 15)


Multiple human pathologies have been attributed to oxidative/nitrosative stress. Stress occurs when the production of reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) exceeds the antioxidant capacity. Heat shock proteins (HSP) are closely related families of constitutively expressed and stress-induced cellular proteins that protect cellular homeostasis against heat and other stress stimuli. Oxidative stress is considered a key mediator of HSP induction. This chapter reviews the role of Hsp70 in different disorders associated with oxidative/nitrosative stress with reference to factors affecting Hsp70 gene expression, the role of proteasomes, the anti-apoptotic and anti-inflammatory effects and the relation between heat stress and oxidative stress. Moreover, we address the overexpression of other HSP such as Hsp32, 27, 40 and 60 following oxidative/nitrosative stress.


Heat shock proteins Hsp70 Nitrosative stress NO Oxidative stress 



Silver nanoparticles


Antioxidant responsive element


Heat shock protein 90-binding agent


Heme oxygenase-1


Heat shock elements


Heat shock factor


Heat shock proteins




Inducible nitric-oxide synthase


Nuclear factor kappa beta


Nitric oxide


Nitric-oxide synthase I/ protein kinase G


Optic nerve heads


Reactive nitrogen species


Reactive oxygen species


Rostral ventrolateral medulla


Tumor necrosis factor



The authors would like to thank the support from Histology and Cell Biology Department, Faculty of Medicine, Zagazig University. We also thank many lab members and colleagues for critical and productive collaborations.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Kattaia Asmaa A. A. A. 
    • 1
  • Abd El-Baset Samia A. 
    • 1
  • Eman M. Mohamed
    • 1
  1. 1.Department of Histology and Cell Biology, Faculty of MedicineZagazig UniversityZagazigEgypt

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