Role of Heat Shock Proteins in Oxidative Stress and Stress Tolerance

  • Sumit Ghosh
  • Poulami Sarkar
  • Priyanka Basak
  • Sushweta Mahalanobish
  • Parames C. SilEmail author
Part of the Heat Shock Proteins book series (HESP, volume 15)


Heat shock proteins (HSP) also referred to as stress proteins are a family of proteins produced by cells in response to exposure to stressful conditions like heat, cold, different kinds of environmental stress, such as infection, inflammation, exercise, exposure of the cell to toxins (ethanol, arsenic, trace metals, and UV light, among many others), starvation, hypoxia (oxygen deprivation), nitrogen deficiency (in plants), water deprivation and during wound healing or tissue remodeling. In this review, the authors have elucidated the role of heat shock proteins in stress tolerance both in eukaryotes and prokaryotes. Here, the role of heat shock proteins in survival during more extreme conditions and maintenance of normal cellular homeostasis have also been briefly discussed.


Heat shock element Heat shock factor Heat shock proteins Oxidative stress Stress tolerance 



The authors thank Bose Institute, Kolkata for providing the facility needed to gather information in relation to this chapter.


  1. Abele D, Tesch C, Wencke P, Pörtner HO (2001) How does oxidative stress relate to thermal tolerance in the Antarctic bivalve Yoldia eightsi? Antarct Sci 13:111–118CrossRefGoogle Scholar
  2. Ahn Y-J, Song N-H (2012) A cytosolic heat shock protein expressed in carrot (Daucus carota L.) enhances cell viability under oxidative and osmotic stress conditions. Hortscience 47:143–148Google Scholar
  3. Ahn Y-J, Claussen K, Zimmerman JL (2004) Genotypic differences in the heat-shock response and thermotolerance in four potato cultivars. Plant Sci 166:901–911CrossRefGoogle Scholar
  4. Amin J, Ananthan J, Voellmy R (1988) Key features of heat shock regulatory elements. Mol Cell Biol 8:3761–3769CrossRefGoogle Scholar
  5. Andersen JK (2004) Oxidative stress in neurodegeneration: cause or consequence? Nat Med 10CrossRefGoogle Scholar
  6. Arrigo A-P (1994) Expression and function of the low-molecular-weight heat shock proteins. The biology of heat shock proteins and molecular chaperones, 335–373Google Scholar
  7. Bakthisaran R, Tangirala R, Rao CM (2015) Small heat shock proteins: role in cellular functions and pathology. Biochim Biophys Acta Proteins Proteomics 1854:291–319CrossRefGoogle Scholar
  8. Basu N, Todgham A, Ackerman P, Bibeau M, Nakano K, Schulte P, Iwama GK (2002) Heat shock protein genes and their functional significance in fish. Gene 295:173–183CrossRefGoogle Scholar
  9. Bhatnagar-Mathur P, Vadez V, Sharma KK (2008) Transgenic approaches for abiotic stress tolerance in plants: retrospect and prospects. Plant Cell Rep 27:411–424CrossRefGoogle Scholar
  10. Brownell SE, Becker RA, Steinman L (2012) The protective and therapeutic function of small heat shock proteins in neurological diseases. Front Immunol 3:74CrossRefGoogle Scholar
  11. Cai SY, Zhang Y, Xu YP, Qi ZY, Li MQ, Ahammed GJ, Xia XJ, Shi K, Zhou YH, Reiter RJ (2017) HsfA1a upregulates melatonin biosynthesis to confer cadmium tolerance in tomato plants. J Pineal Res 62CrossRefGoogle Scholar
  12. Castegna A, Aksenov M, Thongboonkerd V, Klein JB, Pierce WM, Booze R, Markesbery WR, Butterfield DA (2002) Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, α-enolase and heat shock cognate 71. J Neurochem 82:1524–1532CrossRefGoogle Scholar
  13. Chai Y, Koppenhafer SL, Bonini NM, Paulson HL (1999) Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease. J Neurosci 19:10338–10347CrossRefGoogle Scholar
  14. Christman MF, Morgan RW, Jacobson FS, Ames BN (1985) Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in salmonella typhimurium. Cell 41:753–762CrossRefGoogle Scholar
  15. Cruz T, Kandel R, Brown I (1991) Interleukin 1 induces the expression of a heat-shock gene in chondrocytes. Biochem J 277:327–330CrossRefGoogle Scholar
  16. Cummings CJ, Sun Y, Opal P, Antalffy B, Mestril R, Orr HT, Dillmann WH, Zoghbi HY (2001) Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice. Hum Mol Genet 10:1511–1518CrossRefGoogle Scholar
  17. Di Domenico F, Sultana R, Tiu GF, Scheff NN, Perluigi M, Cini C, Butterfield DA (2010) Protein levels of heat shock proteins 27, 32, 60, 70, 90 and thioredoxin-1 in amnestic mild cognitive impairment: an investigation on the role of cellular stress response in the progression of Alzheimer disease. Brain Res 1333:72–81CrossRefGoogle Scholar
  18. Ding Q, Keller JN (2001) Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins. J Neurochem 77:1010–1017CrossRefGoogle Scholar
  19. Driedonks N, Xu J, Peters JL, Park S, Rieu I (2015) Multi-level interactions between heat shock factors, heat shock proteins, and the redox system regulate acclimation to heat. Front Plant Sci 6Google Scholar
  20. Dwivedi V, Lakhotia SC (2016) Ayurvedic Amalaki Rasayana promotes improved stress tolerance and thus has anti-aging effects in Drosophila melanogaster. J Biosci 41:697–711CrossRefGoogle Scholar
  21. Dwivedi V, Anandan E, Mony RS, Muraleedharan T, Valiathan M, Mutsuddi M, Lakhotia SC (2012) In vivo effects of traditional Ayurvedic formulations in Drosophila melanogaster model relate with therapeutic applications. PLoS One 7:e37113CrossRefGoogle Scholar
  22. Feige, U., Morimoto, R.I., Polla, B. (2013) Stress-inducible cellular responses. Birkhäuser Google Scholar
  23. Friedlander RM (2003) Apoptosis and caspases in neurodegenerative diseases. N Engl J Med 348:1365–1375CrossRefGoogle Scholar
  24. Fu C, Liu X, Yang W, Zhao C, Liu J (2016) Enhanced salt tolerance in tomato plants constitutively expressing heat-shock protein in the endoplasmic reticulum. Genet Mol Res 15Google Scholar
  25. Golenhofen N, Redel A, Wawrousek E, Drenckhahn D (2006) Ischemia-induced increase of stiffness of αB-crystallin/HSPB2-deficient myocardium. Pflugers Arch 451:518–525CrossRefGoogle Scholar
  26. González K, Gaitán-Espitia J, Font A, Cárdenas CA, González-Aravena M (2016) Expression pattern of heat shock proteins during acute thermal stress in the Antarctic Sea urchin, Sterechinus neumayeri. Rev Chil Hist Nat 89:2CrossRefGoogle Scholar
  27. Guzhova IV, Arnholdt AC, Darieva ZA, Kinev AV, Lasunskaia EB, Nilsson K, Bozhkov VM, Voronin AP, Margulis BA (1998) Effects of exogenous stress protein 70 on the functional properties of human promonocytes through binding to cell surface and internationalization. Cell Stress Chaperones 3:67CrossRefGoogle Scholar
  28. Hao X, Zhang S, Timakov B, Zhang P (2007) The Hsp27 gene is not required for drosophila development but its activity is associated with starvation resistance. Cell Stress Chaperones 12:364–372CrossRefGoogle Scholar
  29. Heckathorn SA, Downs CA, Sharkey TD, Coleman JS (1998) The small, methionine-rich chloroplast heat-shock protein protects photosystem II electron transport during heat stress. Plant Physiol 116:439–444CrossRefGoogle Scholar
  30. Hossain MA, Li Z-G, Hoque TS, Burritt DJ, Fujita M, Munné-Bosch S (2017) Heat or cold priming-induced cross-tolerance to abiotic stresses in plants: key regulators and possible mechanisms. Protoplasma:1–14Google Scholar
  31. Huang Y-C, Niu C-Y, Yang C-R, Jinn T-L (2016) The heat stress factor HSFA6b connects ABA signaling and ABA-mediated heat responses. Plant Physiol 172:1182–1199PubMedPubMedCentralGoogle Scholar
  32. Iryani MTM, MacRae TH, Panchakshari S, Tan J, Bossier P, Wahid MEA, Sung YY (2017) Knockdown of heat shock protein 70 (Hsp70) by RNAi reduces the tolerance of Artemia franciscana nauplii to heat and bacterial infection. J Exp Mar Biol Ecol 487:106–112CrossRefGoogle Scholar
  33. Jacob P, Hirt H, Bendahmane A (2016) The heat shock protein/chaperone network and multiple stress resistance. Plant Biotechnol JGoogle Scholar
  34. Johnson AD, Berberian PA, Bond MG (1990) Effect of heat shock proteins on survival of isolated aortic cells from normal and atherosclerotic cynomolgus macaques. Atherosclerosis 84:111–119CrossRefGoogle Scholar
  35. Johnson AD, Berberian PA, Tytell M, Bond MG (1995) Differential distribution of 70-kD heat shock protein in atherosclerosis. Arterioscler Thromb Vasc Biol 15:27–36CrossRefGoogle Scholar
  36. Junprung W, Supungul P, Tassanakajon A (2017) HSP70 and HSP90 are involved in shrimp Penaeus vannamei tolerance to AHPND-causing strain of Vibrio parahaemolyticus after non-lethal heat shock. Fish Shellfish Immunol 60:237–246CrossRefGoogle Scholar
  37. Kim H, Ahn Y-J (2009) Expression of a gene encoding the carrot HSP17. 7 in Escherichia coli enhances cell viability and protein solubility under heat stress. Hortscience 44:866–869Google Scholar
  38. Kregel KC (2002) Invited review: heat shock proteins: modifying factors in physiological stress responses and acquired thermotolerance. J Appl Physiol 92:2177–2186CrossRefGoogle Scholar
  39. Kurino C, Furuhashi T, Sudoh K, Sakamoto K (2017) Isoamyl alcohol odor promotes longevity and stress tolerance via DAF-16 in Caenorhabditis elegans. Biochem Biophys Res Commun 485:395–399CrossRefGoogle Scholar
  40. Kuzmin EV, Karpova OV, Elthon TE, Newton KJ (2004) Mitochondrial respiratory deficiencies signal up-regulation of genes for heat shock proteins. J Biol Chem 279:20672–20677CrossRefGoogle Scholar
  41. Lee S-H, Lee K-W, Lee D-G, Son D, Park SJ, Kim K-Y, Park HS, Cha J-Y (2015) Identification and functional characterization of Siberian wild rye (Elymus sibiricus L.) small heat shock protein 16.9 gene (EsHsp16. 9) conferring diverse stress tolerance in prokaryotic cells. Biotechnol Lett 37:881–890CrossRefGoogle Scholar
  42. Li Z, Menoret A, Srivastava P (2002) Roles of heat-shock proteins in antigen presentation and cross-presentation. Curr Opin Immunol 14:45–51CrossRefGoogle Scholar
  43. Li Z, Long R, Zhang T, Wang Z, Zhang F, Yang Q, Kang J, Sun Y (2017) Molecular cloning and functional analysis of the drought tolerance gene MsHSP70 from alfalfa (Medicago sativa L.). J Plant Res 130:387–396CrossRefGoogle Scholar
  44. Lindquist S, Craig E (1988) The heat-shock proteins. Annu Rev Genet 22:631–677CrossRefGoogle Scholar
  45. Liu X-d, Thiele DJ (1996) Oxidative stress induced heat shock factor phosphorylation and HSF-dependent activation of yeast metallothionein gene transcription. Genes Dev 10:592–603CrossRefGoogle Scholar
  46. Liu C, Fu J, Xu F, Wang X, Li S (2015) The role of heat shock proteins in oxidative stress damage induced by se deficiency in chicken livers. Biometals 28:163–173CrossRefGoogle Scholar
  47. Liu Y, Ma D, Zhao C, Xiao Z, Xu S, Xiao Y, Wang Y, Liu Q, Li J (2017) The expression pattern of hsp70 plays a critical role in thermal tolerance of marine demersal fish: multilevel responses of Paralichthys olivaceus and its hybrids (P. Olivaceus♀× P. Dentatus♂) to chronic and acute heat stress. Mar Environ Res 129:386–395CrossRefGoogle Scholar
  48. Lüders J, Demand J, Höhfeld J (2000) The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome. J Biol Chem 275:4613–4617CrossRefGoogle Scholar
  49. Mahanty A, Purohit GK, Yadav RP, Mohanty S, Mohanty BP (2017) hsp90 and hsp47 appear to play an important role in minnow Puntiussophore for surviving in the hot spring run-off aquatic ecosystem. Fish Physiol Biochem 43:89–102CrossRefGoogle Scholar
  50. Malik MK, Slovin JP, Hwang CH, Zimmerman JL (1999) Modified expression of a carrot small heat shock protein gene, Hsp17. 7, results in increased or decreased thermotolerance. Plant J 20:89–99CrossRefGoogle Scholar
  51. Mattson MP (2000) Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol 1:120CrossRefGoogle Scholar
  52. Mc Naughton L, Lovell R, Madden L (2006) Heat shock proteins in exercise: a review. J Exerc Sci Physiother 2:13Google Scholar
  53. Melvin P, Bankapalli K, D’Silva P, Shivaprasad P (2017) Methylglyoxal detoxification by a DJ-1 family protein provides dual abiotic and biotic stress tolerance in transgenic plants. Plant Mol Biol:1–17Google Scholar
  54. Mittler R, Kim Y, Song L, Coutu J, Coutu A, Ciftci-Yilmaz S, Lee H, Stevenson B, Zhu J-K (2006) Gain-and loss-of-function mutations in Zat10 enhance the tolerance of plants to abiotic stress. FEBS Lett 580:6537–6542CrossRefGoogle Scholar
  55. Moraitis C, Curran BP (2004) Reactive oxygen species may influence the heat shock response and stress tolerance in the yeast Saccharomyces cerevisiae. Yeast 21:313–323CrossRefGoogle Scholar
  56. Morimoto RI, Santoro MG (1998) Stress–inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection. Nat Biotechnol 16:833–838CrossRefGoogle Scholar
  57. Morrison LE, Whittaker RJ, Klepper RE, Wawrousek EF, Glembotski CC (2004) Roles for αB-crystallin and HSPB2 in protecting the myocardium from ischemia-reperfusion-induced damage in a KO mouse model. Am J Phys Heart Circ Phys 286:H847–H855Google Scholar
  58. Muchowski PJ, Wacker JL (2005) Modulation of neurodegeneration by molecular chaperones. Nat Rev Neurosci 6:11CrossRefGoogle Scholar
  59. Mymrikov EV, Seit-Nebi AS, Gusev NB (2011) Large potentials of small heat shock proteins. Physiol Rev 91:1123–1159CrossRefGoogle Scholar
  60. Najarzadegan M, Ataei E, Akbarzadeh F (2016) The role of heat shock proteins in Alzheimer disease: a systematic review. J Syndr 3:6Google Scholar
  61. Nakai A, Tanabe M, Kawazoe Y, Inazawa J, Morimoto RI, Nagata K (1997) HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator. Mol Cell Biol 17:469–481CrossRefGoogle Scholar
  62. Neta-Sharir I, Isaacson T, Lurie S, Weiss D (2005) Dual role for tomato heat shock protein 21: protecting photosystem II from oxidative stress and promoting color changes during fruit maturation. Plant Cell 17:1829–1838CrossRefGoogle Scholar
  63. Nguyen XC, Hoang MHT, Kim HS, Lee K, Liu X-M, Kim SH, Bahk S, Park HC, Chung WS (2012) Phosphorylation of the transcriptional regulator MYB44 by mitogen activated protein kinase regulates Arabidopsis seed germination. Biochem Biophys Res Commun 423:703–708CrossRefGoogle Scholar
  64. Padmini E, Rani MU (2011) Heat-shock protein 90 alpha (HSP90α) modulates signaling pathways towards tolerance of oxidative stress and enhanced survival of hepatocytes of Mugil cephalus. Cell Stress Chaperones 16:411–425CrossRefGoogle Scholar
  65. Pandey A, Saini S, Khatoon R, Sharma D, Narayan G, Chowdhuri DK (2016) Overexpression of hsp27 rescued neuronal cell death and reduction in life-and health-span in drosophila melanogaster against prolonged exposure to dichlorvos. Mol Neurobiol 53:3179–3193CrossRefGoogle Scholar
  66. Pérez-Salamó I, Papdi C, Rigó G, Zsigmond L, Vilela B, Lumbreras V, Nagy I, Horváth B, Domoki M, Darula Z (2014) The heat shock factor A4A confers salt tolerance and is regulated by oxidative stress and the mitogen-activated protein kinases MPK3 and MPK6. Plant Physiol 165:319–334CrossRefGoogle Scholar
  67. Perisic O, Xiao H, Lis JT (1989) Stable binding of drosophila heat shock factor to head-to-head and tail-to-tail repeats of a conserved 5 bp recognition unit. Cell 59:797–806CrossRefGoogle Scholar
  68. Pirkkala L, Sistonen L (2001) Heat shock proteins (HSPs): structure, function and genetics. eLS Google Scholar
  69. Pörtner H (2001) Climate change and temperature-dependent biogeography: oxygen limitation of thermal tolerance in animals. Naturwissenschaften 88:137–146CrossRefGoogle Scholar
  70. Rajkumar U, Vinoth A, Rajaravindra K, Shanmugham M, Rao S (2015) Effect of in ovo inoculation of vitamin E on expression of Hsp-70 m RNA and juvenile growth in coloured broiler chicken. Indian J Poult Sci 50:104–108Google Scholar
  71. Rauchova H, Vokurkova M, Koudelova J (2012) Hypoxia-induced lipid peroxidation in the brain during postnatal ontogenesis. Physiol Res 61:S89PubMedGoogle Scholar
  72. Ray PS, Martin JL, Swanson EA, Otani H, Dillmann WH, Das DK (2001) Transgene overexpression of αB crystallin confers simultaneous protection against cardiomyocyte apoptosis and necrosis during myocardial ischemia and reperfusion. FASEB J 15:393–402CrossRefGoogle Scholar
  73. Ritossa F (1964) Experimental activation of specific loci in polytene chromosomes of drosophila. Exp Cell Res 35:601–607CrossRefGoogle Scholar
  74. Robinson MB, Tidwell JL, Gould T, Taylor AR, Newbern JM, Graves J, Tytell M, Milligan CE (2005) Extracellular heat shock protein 70: a critical component for motoneuron survival. J Neurosci 25:9735–9745CrossRefGoogle Scholar
  75. Russo A, Palumbo M, Scifo C, Cardile V, Barcellona M, Renis M (2001) Ethanol-induced oxidative stress in rat astrocytes: role of HSP70. Cell Biol Toxicol 17:153–168CrossRefGoogle Scholar
  76. Sakthivel K, Watanabe T, Nakamoto H (2009) A small heat-shock protein confers stress tolerance and stabilizes thylakoid membrane proteins in cyanobacteria under oxidative stress. Arch Microbiol 191:319–328CrossRefGoogle Scholar
  77. Santoro MG (2000) Heat shock factors and the control of the stress response. Biochem Pharmacol 59:55–63CrossRefGoogle Scholar
  78. Schuetz TJ, Gallo GJ, Sheldon L, Tempst P, Kingston RE (1991) Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans. Proc Natl Acad Sci 88:6911–6915CrossRefGoogle Scholar
  79. Sedaghatmehr M, Mueller-Roeber B, Balazadeh S (2016) The plastid metalloprotease FtsH6 and small heat shock protein HSP21 jointly regulate thermomemory in Arabidopsis. Nat Commun 7:12439CrossRefGoogle Scholar
  80. Shi Y, Nishida K, Di Giammartino DC, Manley JL (2011) Heat shock-induced SRSF10 dephosphorylation displays thermotolerance mediated by Hsp27. Mol Cell Biol 31:458–465CrossRefGoogle Scholar
  81. Sistonen L, Sarge K, Phillips B, Abravaya K, Morimoto R (1992) Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells. Mol Cell Biol 12:4104–4111CrossRefGoogle Scholar
  82. Song N-H, Ahn Y-J (2010) DcHsp17. 7, a small heat shock protein from carrot, is upregulated under cold stress and enhances cold tolerance by functioning as a molecular chaperone. Hortscience 45:469–474Google Scholar
  83. Song N-H, Ahn Y-J (2011) DcHsp17. 7, a small heat shock protein in carrot, is tissue-specifically expressed under salt stress and confers tolerance to salinity. New Biotechnol 28:698–704CrossRefGoogle Scholar
  84. Song C, Chung WS, Lim CO (2016) Overexpression of heat shock factor gene HsfA3 increases Galactinol levels and oxidative stress tolerance in Arabidopsis. Mol Cells 39:477CrossRefGoogle Scholar
  85. Sørensen JG (2010) Application of heat shock protein expression for detecting natural adaptation and exposure to stress in natural populations. Curr Zool 56:703–713Google Scholar
  86. Sun Y, MacRae TH (2005) The small heat shock proteins and their role in human disease. FEBS J 272:2613–2627CrossRefGoogle Scholar
  87. Suzuki K, Sawa Y, Kaneda Y, Ichikawa H, Shirakura R, Matsuda H (1997) In vivo gene transfection with heat shock protein 70 enhances myocardial tolerance to ischemia-reperfusion injury in rat. J Clin Investig 99:1645CrossRefGoogle Scholar
  88. Tanabe M, Kawazoe Y, Takeda S, Morimoto RI, Nagata K, Nakai A (1998) Disruption of the HSF3 gene results in the severe reduction of heat shock gene expression and loss of thermotolerance. EMBO J 17:1750–1758CrossRefGoogle Scholar
  89. Tidwell JL, Houenou LJ, Tytell M (2004) Administration of Hsp70 in vivo inhibits motor and sensory neuron degeneration. Cell Stress Chaperones 9:88–98CrossRefGoogle Scholar
  90. Tiwari S, Thakur R, Shankar J (2015) Role of heat-shock proteins in cellular function and in the biology of fungi. Biotechnol Res Int 2015:1CrossRefGoogle Scholar
  91. Tóth ME, Gombos I, Sántha M (2015) Heat shock proteins and their role in human diseases. Acta Biol Szeged 59:121–141Google Scholar
  92. Tytell M, Greenberg S, Lasek R (1986) Heat shock-like protein is transferred from glia to axon. Brain Res 363:161–164CrossRefGoogle Scholar
  93. Umapathy D, Krishnamoorthy E, Muthukumaran P, Rajaram R, Padmalayam I, Viswanathan V (2012) Association of A1538G and C2437T single nucleotide polymorphisms in heat shock protein 70 genes with type 2 diabetes. Lab Med 43:250–255CrossRefGoogle Scholar
  94. Usman MG, Rafii M, Ismail M, Malek M, Latif MA, Oladosu Y (2014) Heat shock proteins: functions and response against heat stress in plants. Int J Sci Technol Res 3:204–218Google Scholar
  95. Wang H-D, Kazemi-Esfarjani P, Benzer S (2004) Multiple-stress analysis for isolation of drosophila longevity genes. Proc Natl Acad Sci U S A 101:12610–12615CrossRefGoogle Scholar
  96. Wang M, Zou Z, Li Q, Sun K, Chen X, Li X (2017) The CsHSP17. 2 molecular chaperone is essential for thermotolerance in Camellia sinensis. Sci Rep 7:1237CrossRefGoogle Scholar
  97. Warrick JM, Chan HE, Gray-Board GL, Chai Y, Paulson HL, Bonini NM (1999) Suppression of polyglutamine-mediated neurodegeneration in drosophila by the molecular chaperone HSP70. Nat Genet 23:425–428CrossRefGoogle Scholar
  98. Whitley D, Goldberg SP, Jordan WD (1999) Heat shock proteins: a review of the molecular chaperones. J Vasc Surg 29:748–751CrossRefGoogle Scholar
  99. Wilhelmus M, Otte-Höller I, Wesseling P, De Waal R, Boelens W, Verbeek M (2006) Specific association of small heat shock proteins with the pathological hallmarks of Alzheimer's disease brains. Neuropathol Appl Neurobiol 32:119–130CrossRefGoogle Scholar
  100. Wu D, Cederbaum AI (2003) Alcohol, oxidative stress, and free radical damage. Alcohol Res Health 27:277–284PubMedGoogle Scholar
  101. Wyttenbach A, Arrigo AP (2009) The role of heat shock proteins during neurodegeneration in Alzheimer’s, Parkinson’s and Huntington’s disease. In: Heat shock proteins in neural cells, pp 81–99CrossRefGoogle Scholar
  102. Wyttenbach A, Sauvageot O, Carmichael J, Diaz-Latoud C, Arrigo A-P, Rubinsztein DC (2002) Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin. Hum Mol Genet 11:1137–1151CrossRefGoogle Scholar
  103. Yoshida T, Ohama N, Nakajima J, Kidokoro S, Mizoi J, Nakashima K, Maruyama K, Kim J-M, Seki M, Todaka D (2011) Arabidopsis HsfA1 transcription factors function as the main positive regulators in heat shock-responsive gene expression. Mol Gen Genomics 286:321–332CrossRefGoogle Scholar
  104. Yu Q, Kent CR, Tytell M (2001) Retinal uptake of intravitreally injected Hsc/Hsp70 and its effect on susceptibility to light damage. Mol Vis 7:48–56PubMedGoogle Scholar

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Sumit Ghosh
    • 1
  • Poulami Sarkar
    • 1
  • Priyanka Basak
    • 1
  • Sushweta Mahalanobish
    • 1
  • Parames C. Sil
    • 1
    Email author
  1. 1.Division of Molecular MedicineBose InstituteKolkataIndia

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