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Modeling Schizophrenia with Human Stem Cells

  • Juliana Minardi Nascimento
  • Veronica M. Saia-Cereda
  • Giuliana S. Zuccoli
  • Danielle Gouvêa-Junqueira
  • Daniel Martins-de-Souza
Chapter

Abstract

The complexity of psychiatric disorders is a challenge still to overcome, and schizophrenia has been the most prevalent yet little understood. Several studies have used knowledge from postmortem brain tissue and other models, to address difficult questions regarding diagnostic and treatment. An improvement in the translational capacity of molecular profiling studies of psychiatric disorders was achieved with the development of human-induced pluripotent stem cells (iPSCs), through provision of human neuronal-like tissue. The finding that iPSCs can recapitulate the phenotype of the donor also affords the possibility of using this approach to study both the disease and control states in a given medical area.

Keywords

Brain iPSC Neural cell Neurodevelopment Psychiatric disorders 

Notes

Acknowledgments

JMN, VMSC, GSZ, and DMS are supported by the São Paulo Research Foundation (FAPESP) grants 14/21035-0, 16/07332-7, 16/04912-2, 13/08711-3, and 14/10068-4.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Juliana Minardi Nascimento
    • 1
    • 2
  • Veronica M. Saia-Cereda
    • 1
  • Giuliana S. Zuccoli
    • 1
  • Danielle Gouvêa-Junqueira
    • 1
  • Daniel Martins-de-Souza
    • 1
    • 4
    • 3
  1. 1.Lab of Neuroproteomics, Department of Biochemistry and Tissue BiologyInstitute of Biology, University of Campinas (UNICAMP)CampinasBrazil
  2. 2.D’Or Institute for Research and Education (IDOR)Rio de JaneiroBrazil
  3. 3.Instituto Nacional de Biomarcadores em Neuropsiquiatria (INBION) Conselho Nacional de Desenvolvimento Cientifico e TecnologicoSão PauloBrazil
  4. 4.UNICAMP’s Neurobiology CenterCampinasBrazil

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