Novel Constructs—Half-Life Extensions

  • Jeonghoon SunEmail author
  • Mark Michaels
Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 38)


A dearth of biologics have been developed and used as therapeutics for numerous disease indications, including IgG monoclonal antibodies, non-IgG recombinant proteins, bi- and multi-specific antibodies, and antibody drug conjugates. A remarkable portion of these biologic constructs exhibits a short plasma half-life that results in a significant reduction in therapeutic efficacy. Frequently, biologic drugs need to be designed to maintain the effective concentration range during the therapeutic window with an extended serum half-life. Provided here is a comprehensive overview of various half-life extension methods involving FcRn engagement, chemical and genetic fusion, post-translational modifications and formulation.


Half-life extension FcRn PEGylation Human serum albumin Fc loop 


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Copyright information

© American Association of Pharmaceutical Scientists 2018

Authors and Affiliations

  1. 1.Department of BiotherapeuticsCelgene CorporationSan DiegoUSA
  2. 2.Amgen Inc.One Amgen Center DriveThousand OaksUSA

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