Microbiome and Gut Immunity: B Cells

  • Oliver PabstEmail author


The intestinal mucosa is protected by secretory immunoglobulins (SIgs). SIgs are produced by the combined function of plasma cells and stroma cells, primarily the gut epithelial cells, and constitute the main type of antibody produced in mice and humans. After their release into the gut lumen, SIgs regulate the composition of the microbiota, neutralize toxins, and prevent infections. In this chapter, the organization of the intestinal B cell compartment, pathways of SIg generation, and the function of SIg in regulating the intestinal microbiota will be discussed.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Institute of Molecular Medicine, RWTH Aachen UniversityAachenGermany

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