Neonatal Critical Care Nephrology

  • David AskenaziEmail author
  • Vesna Stojanović


Extraordinary advancements in neonatal care have markedly reduced mortality of infants hospitalized in Neonatal Intensive Care Unit (NICU). Over the last decade, studies show that neonatal acute kidney injury (AKI) is common and those with AKI have higher mortality and prolonged length of stay. The most common accepted definition of the neonatal AKI is based on a rise in serum creatinine and/or decrease in urine output. Premature infants are born with low nephron numbers which predisposes them to AKI and chronic kidney disease (CKD). Despite recent insights that substantiate the impact of poor kidney health on outcomes in sick neonates, significant critical gaps in our understanding of the antenatal and postnatal factors exist. The global burden of AKI and CKD in NICU graduates need to be better understood. Fortunately, progress is being made as investigators are performing large observational studies, and randomized clinical trials that evaluate risk factors, outcomes, and interventions. Peritoneal dialysis is a method of choice for kidney function replacement in newborns. In addition, novel machines, with smaller extracorporeal volume, designed to provide renal support for neonates have been designed and are currently in use in a few centers around the world.


Acute kidney injury Newborn ADD ACUTE RENAL FAILURE 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Pediatric Nephrology, Department of PediatricsPediatric and Infant Center for Acute Nephrology, University of Alabama at BirminghamBirminghamUSA
  2. 2.Medical Faculty, Department of PediatricsNovi SadSerbia
  3. 3.Intermediate Intensive Care UnitInstitute of Child and Youth Health Care of VojvodinaNovi SadSerbia

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