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Porcine Reproductive and Respiratory Syndrome (PRRS)

  • Elizabeth Loza-Rubio
  • Edith Rojas-Anaya
Chapter

Abstract

Porcine reproductive and respiratory syndrome (PRRS) is an economically frustrating viral disease of pigs, characterized by severe reproductive failure in pregnant sows and respiratory disorders in piglets and growing pigs. Several research groups around the world have developed PRRSV vaccines. Some of these have been effective; however, owing to the complications that the syndrome presents and the viral evasion of the immune system, vaccines have not always been 100% effective. Biotechnological tools, such as the generation of plant-derived vaccines, offer alternatives to obtain more stable biologics, free of fermentation and cold chains. According to the literature, these vaccines are cost effective. In this document, we present some of the vaccines that have been developed against PRRSV, both traditional and new, and describe some alternatives developed in plants.

Keywords

PRRS Traditional vaccines New generation vaccines 

References

  1. Bai X, Wang Y, Xu X, Sun Z, Xiao Y, Ji G, Li Y, Tan F, Li X, Tian K (2016) Commercial vaccines provide limited protection to NADC30-like PRRSV infection. Vaccine 34:5540–5545CrossRefPubMedGoogle Scholar
  2. Brar MS, Shi M, Murtaugh MP, Leung FC (2015) Evolutionary diversification of type 2 porcine reproductive and respiratory syndrome virus. J Gen Virol 96:1570–1580CrossRefPubMedGoogle Scholar
  3. Chan HT, Chia MY, Pang VF, Jeng CR, Do YY, Huang PL (2013) Oral immunogenicity of porcine reproductive and respiratory syndrome virus antigen expressed in transgenic banana. Plant Biotechnol J 11:315–324CrossRefPubMedGoogle Scholar
  4. Chand RJ, Trible BR, Rowland RR (2012) Pathogenesis of porcine reproductive and respiratory syndrome virus. Curr Opin Virol 2:256–263CrossRefPubMedGoogle Scholar
  5. Charerntantanakul W (2012) Porcine reproductive and respiratory syndrome virus vaccines: immunogenicity, efficacy and safety aspects. World J Virol 1:23–30CrossRefPubMedPubMedCentralGoogle Scholar
  6. Chen X, Liu J (2011) Generation and immunogenicity of transgenic potato expressing the GP5 protein of porcine reproductive and respiratory syndrome virus. J Virol Methods 173:153–158CrossRefPubMedGoogle Scholar
  7. Chia MY, Hsiao SH, Chan HT, Do YY, Huang PL, Chang HW, Tsai YC, Lin CM, Pang VF, Jeng CR (2010) Immunogenicity of recombinant GP5 protein of porcine reproductive and respiratory syndrome virus expressed in tobacco plant. Vet Immunol Immunopathol 135:234–242CrossRefPubMedGoogle Scholar
  8. Chia MY, Hsiao SH, Chan HT, Do YY, Huang PL, Chang HW, Tsai YC, Lin CM, Pang VF, Jeng CR (2011) Evaluation of the immunogenicity of a transgenic tobacco plant expressing the recombinant fusion protein of GP5 of porcine reproductive and respiratory syndrome virus and B subunit of Escherichia coli heat-labile enterotoxin in pigs. Vet Immunol Immunopathol 140:215–225CrossRefPubMedGoogle Scholar
  9. Chung CJ, Cha S-H, Grimm AL, ChungG Gibson KA, Yoon K-J et al (2016) Recognition of highly diverse Type-1 and -2 porcine reproductive and respiratory syndrome viruses (PRRSVs) by T-Lymphocytes induced in pigs after experimental infection with a Type-2 PRRSV strain. PLoS ONE 11:e0165450CrossRefPubMedPubMedCentralGoogle Scholar
  10. Collins JE, Banfield DA, Christianson WT, Harris L, Hennings JC, Shaw DP et al (1992) Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR-2332) in North America and experimental reproduction of the disease in gnotobiotic pigs. J Vet Diagn Invest 4:117–126CrossRefPubMedGoogle Scholar
  11. Corzo CA, Mondaca E, Wayne S, Torremorell M, Dee S, Davies P, Morrison RB (2010) Control and elimination of porcine reproductive and respiratory syndrome virus. Virus Res 154:185–192CrossRefPubMedGoogle Scholar
  12. Diosdado VF, Socci EG, Martínez LCA, Carrera SME (2015) Síndrome reproductivo y respiratorio porcino (PRRS). Folleto para productores N° 1. INIFAP, Mexico. ISBN 978-607-37-0412-0. Junio, 2015, pp 1–15Google Scholar
  13. Dockland T (2010) The structural biology of PRRSV. Virus Res 154:86–97CrossRefGoogle Scholar
  14. Drigo M, Franzo G, Gigli H, Martini M, Mondin A, Gracieux P, Ceglie L (2014) The impact of porcine reproductive and respiratory syndrome virus genetic heterogeneity on molecular assay performances. J Virol Meth 202:79–86CrossRefGoogle Scholar
  15. Forsberg R (2005) Divergence time of porcine reproductive and respiratory syndrome virus subtypes. Mol Biol Evol 22:2131–2134CrossRefPubMedGoogle Scholar
  16. Geldhof MF, Vanhee M, Van BW, Van DJ, Karniychuk UU, Nauwynck HJ (2012) Comparison of the efficacy of autogenous inactivated Porcine reproductive and respiratory syndrome virus (PRRSV) vaccines with that of commercial vaccines against homologous and heterologous challenges. BMC Vet Res 8:182CrossRefPubMedPubMedCentralGoogle Scholar
  17. Goldberg TL, Lowe JF, Milburn SM, Firkins LD (2003) Quasispecies variation of Porcine reproductive and respiratory syndrome virus during natural infection. Virology 317:4069–4080CrossRefGoogle Scholar
  18. Han D, Hu Y, Li L, Tian H, Chen Z, Wang L, Ma H, Yang H, Teng K (2014) Highly pathogenic porcine reproductive and respiratory syndrome virus infection results in acute lung injury of the infected pigs. Vet Microbiol 169:135–146CrossRefPubMedGoogle Scholar
  19. Hill H (1990) Overview and history of mystery swine disease (swine infertility/respiratory syndrome). In Proceedings of the mystery swine disease committee meeting, 1990. Denver, CO, pp 29–30. Public Livestock Conservation Institute, Madison, WIGoogle Scholar
  20. Holtkamp DJ, Kliebenstein JB, Neumann EJ, Zimmerman JJ, Rotto HF, Yoder TK, Wang C, Yeske PE, Mowrer CL, Haley CA (2013) Assessment of the economic impact of porcine reproductive and respiratory syndrome virus on United States pork producers. J Swine Health Prod 21:72–84Google Scholar
  21. Hu J, Ni Y, Dryman BA, Meng XJ, Zhang C (2012) Immunogenicity study of plant-made oral subunit vaccine against porcine reproductive and respiratory syndrome virus (PRRSV). Vaccine 30:2068–2074CrossRefPubMedGoogle Scholar
  22. Kheyar A, Jabrane A, Zhu C, Cléroux P, Massie B, Dea S, Gagnon CA (2005) Alternative codon usage of PRRS virus ORF5 gene increases eucaryotic expression of GP(5) glycoprotein and improves immune response in challenged pigs. Vaccine 23:4016–4022CrossRefPubMedGoogle Scholar
  23. Kappes MA, Faaberg KS (2015) PRRSV structure, replication and recombination: origin of phenotype and genotype diversity. Virology 479–480:475–486CrossRefPubMedGoogle Scholar
  24. Karniychuk UU, Nauwynck HJ (2013) Pathogenesis and prevention of placental and transplacental porcine reproductive and respiratory syndrome virus infection. Vet Res 44:95CrossRefPubMedPubMedCentralGoogle Scholar
  25. Karniychuk UU, Saha D, Geldhof M, Vanhee M, Cornillie P, Broeck W, Nauwynck HJ (2011) Porcine reproductive and respiratory syndrome virus (PRRSV) causes apoptosis during its replication in fetal implantation sites. Microb Pathog 51:194–202CrossRefPubMedGoogle Scholar
  26. Karniychuk UU, Spiegelaere WD, Nauwynck HJ (2013) Porcine reproductive and respiratory syndrome virus infection is associated with an increased number of Sn- positive and CD8-positive cells in the maternal-fetal interface. Virus Res 176:285–291CrossRefPubMedGoogle Scholar
  27. Ladinig A, Ashley C, Detmer SE, Wilkinson JM, Lunney JK, Plastow G, Harding JCS (2015) Maternal and fetal predictors of fetal viral load and death in third trimester, type 2 porcine reproductive and respiratory syndrome virus infected pregnant gilts. Vet Res 46:107CrossRefPubMedPubMedCentralGoogle Scholar
  28. Linhares DC, Cano JP, Torremorell M, Morrison RB (2014) Comparison of time to PRRSv-stability and production losses between two exposure programs to control PRRSv in sow herds. Prev Vet Med. 116:111–119CrossRefPubMedGoogle Scholar
  29. Linhares DCL, Johnson C, Morrison RB (2015) Economic analysis of vaccination strategies for PRRS control. PLoS ONE 10:e0144265CrossRefPubMedPubMedCentralGoogle Scholar
  30. Liu Y, Shi W, Zhou E, Wang S, Hu S, Cai X, Rong F, Wu J, Xu M, Xu M, Li L (2010) Dynamic changes in inflammatory cytokines in pigs infected with highly pathogenic porcine reproductive and respiratory syndrome virus. Clin Vaccine Immunol 17:1439–1445CrossRefPubMedPubMedCentralGoogle Scholar
  31. Lopez OJ, Osorio FA (2004) Role of neutralizing antibodies in PRRSV protective immunity. Vet Immunol Immunopathol 102:155–163CrossRefPubMedGoogle Scholar
  32. Loving CL, Osorio FA, Murtaugh MP, Zuckermann FA (2015) Innate and adaptive immunity against porcine reproductive and respiratory syndrome virus. Vet Immunol Immunopathol 167:1–14CrossRefPubMedGoogle Scholar
  33. Loza-Rubio E, Rojas-Anaya E (2014) Case study 1: rabies. In: Hefferon KL (ed) Plant–derived pharmaceuticals. Principles and applications for developing countries. CABI Biotechnologies series, Ithaca NY, USA, pp 117–136Google Scholar
  34. Luping D, Bin L, Kongwang H, Haibin Z, Kehe H, Shaobo X (2013) Construction and immunogenicity of DNA vaccines encoding fusion protein of porcine IFN-g1 and GP5 gene of porcine reproductive and respiratory syndrome virus. Biomed Res Int 2013:318698Google Scholar
  35. Meulenberg J (2000) PRRSV, the virus. Vet Res 31:11–21PubMedGoogle Scholar
  36. Murtaugh MP, Genzow M (2011) Immunological solutions for treatment and prevention of porcine reproductive and respiratory syndrome (PRRS). Vaccine 29:8192–8204CrossRefPubMedGoogle Scholar
  37. Murtaugh MP, Stadejek T, Abrahante JE, Lam TTY, Leung FC (2010) The ever expanding diversity of porcine reproductive and respiratory syndrome virus. Virus Res 154:18–30CrossRefPubMedGoogle Scholar
  38. Neumann EJ, Kliebenstein JB, Johnson CD, Mabry JW, Bush EJ, Seitzinger AH, Green AL, Zimmerman JJ (2005) Assessment of the economic impact of porcine reproductive and respiratory syndrome on swine production in the United States. J Am Vet Med Assoc 227:385–392CrossRefPubMedGoogle Scholar
  39. Nieuwenhuis N, Duinhof TF, van Nes A (2012) A economic analysis of outbreaks of porcine reproductive and respiratory syndrome virus in nine sow herds. Vet Rec 170:225CrossRefPubMedGoogle Scholar
  40. Novakovic P, Harding JCS, Al-Dissi AN, Ladinig A, Detmer SE (2016) Pathologic evaluation of Type-2 porcine reproductive and respiratory syndrome virus infection at the maternal-fetal interface of Late gestation pregnant gilts. PLoS ONE 11:e0151198CrossRefPubMedPubMedCentralGoogle Scholar
  41. Palzer A, Haedke K, Heinritzi K, Zoels S, Ladinig A, Ritzmann M (2015) Associations among Haemophilus parasuis, Mycoplasma hyorhinis, and porcine reproductive and respiratory syndrome virus infections in pigs with polyserositis. Can Vet J 56:285–287PubMedPubMedCentralGoogle Scholar
  42. Pileri E, Mateu E (2016) Review on the transmission porcine reproductive and respiratory syndrome virus between pigs and farms and impact in vaccination. Vet Res 47:108CrossRefPubMedPubMedCentralGoogle Scholar
  43. Pileri E, Gibert E, Martín-Valls GE, Nofrarias M, López-Soria S, Martín M, Díaz I, Darwich L, Mateu E (2017) Transmission of porcine reproductive and respiratory syndrome virus 1 to and from vaccinated pigs in a one-to-one model. Vet Microbiol 201:18–25CrossRefPubMedGoogle Scholar
  44. Plana J, Vayreda M, Vilarrasa J, Bastons M, Rosell R, Martinez M, San Gabriel A, Pujols J, Badiola JL et al (1992) Porcine epidemic abortion and respiratory syndrome (mystery swine disease). Isolation in Spain of the causative agent and experimental reproduction of the disease. Vet Microbiol 33:203–211CrossRefPubMedGoogle Scholar
  45. Piron R, De Koker S, De Paepe A, Goossens J, Grooten J, Nauwynck H, Depicker A (2014a) Boosting in planta production antigens derived from the porcine reproductive and respiratory syndrome virus (PRRSV) and subsequent evaluation of their immunogenicity. PLoS ONE 10:e91386CrossRefGoogle Scholar
  46. Piron R, De Koker S, De Paepe A, Goossens J, Grooten J, Nauwynck H, Depicker A (2014b) Boosting in planta production of antigens derived from the porcine reproductive and respiratory syndrome virus (PRRSV) and subsequent evaluation of their immunogenicity. PLoS One 9:e91386CrossRefPubMedPubMedCentralGoogle Scholar
  47. Renukaradhya GJ, Meng XJ, Calvert JG, Roof M, Lager KM (2015) Live porcine reproductive and respiratory syndrome virus vaccine: current status and future direction. Vaccine 33:4069–4080CrossRefPubMedGoogle Scholar
  48. Renson P, Rose N, Le Dimma M, Mahé S, Keranflec’h A, Paboeuf F, Belloc C, Le Potier M-F, Bourry O (2017) Dynamic changes in bronchoalveolar macrophages and cytokines during infection of pigs with a highly or low pathogenic genotype 1 PRRSV strain. Vet Res 48:15Google Scholar
  49. Saroja CH, Lakshmi PK, Bhaskaran S (2011) Recent trends in vaccine delivery systems: a review. Int J of Pharm Invest 1:64–74CrossRefGoogle Scholar
  50. Savard C, Alvarez F, Provot C, Chorfi Y, D’Allaire S, Benoit-Biancamano MO, Gagnon CA (2016) Efficacy of Fostera PRRS modified live virus vaccine against a Canadian heterologous virulent field strain of porcine reproductive and respiratory syndrome virus. Can J Vet Res 80:1–11PubMedPubMedCentralGoogle Scholar
  51. Schweer WP, Schwartz K, Burrough ER, Yoon KJ, Sparks JC, Gabler NK (2016) The effect of porcine reproductive and respiratory syndrome virus and porcine epidemic diarrhea virus challenge on growing pigs I: growth performance and digest. J Anim Sci 94:514–522CrossRefPubMedGoogle Scholar
  52. Shi M, Lam TT, Hon CC, Hui RK, Faaberg KS, Wennblom T, Murtaugh MP, Stadejek T, Leung FC (2010) Molecular epidemiology of PRRSV: a phylogenetic perspective. Virus Res 154:7–17CrossRefPubMedGoogle Scholar
  53. Shi M, Holmes EC, Brar MS, Leung FC (2013) Recombination is associated with an outbreak of novel highly pathogenic porcine reproductive and respiratory syndrome virus in China. J Virol 87:10904–10907CrossRefPubMedPubMedCentralGoogle Scholar
  54. Snijder EJ, Meulenberg JJ (1998) The molecular biology of arteriviruses. J Gen Virol 79:961–979CrossRefPubMedGoogle Scholar
  55. Specht EA, Mayfield SP (2014) Algae-based oral recombinant vaccines. Front Microbiol 5:60CrossRefPubMedPubMedCentralGoogle Scholar
  56. Sun Z, Wang J, Bai X, Ji G, Yan H, Li Y, Wang Y, Tan F, Xiao Y, Li X, Tian K (2016a) Pathogenicity comparison between highly pathogenic and NADC30-like porcine reproductive and respiratory syndrome virus. Arch Virol 161:2257–2261CrossRefPubMedGoogle Scholar
  57. Sun D, Khatun A, Kim WI, Cooper V, Cho YI, Wang C, Choi EJ, Yoon KJ (2016b) Attempts to enhance cross-protection against porcine reproductive and respiratory syndrome viruses using chimeric viruses containing structural genes from two antigenically distinct strains. Vaccine 34:4335–4342CrossRefPubMedGoogle Scholar
  58. Uribe-Campero L, Monrroy-García A, Durán-Meza AL, Villagrana-Escarreñõ MV, Ruiz-García J et al (2015) Plant-based porcine reproductive and respiratory syndrome virus VLPs induce an immune response in mice. Res Vet Sci 102:59–66CrossRefPubMedGoogle Scholar
  59. Van Reeth K, Labarque G, Nauwynck H, Pensaert M (1999) Differential production of proinflammatory cytokines in the pig lung during different respiratory virus infections: correlations with pathogenicity. Res Vet Sci 67:47–52CrossRefPubMedGoogle Scholar
  60. Vimolmangkang S, Gasic K, Soria-Guerra R, Rosales-Mendoza S, Moreno-Fierros L, Korban SS (2012) Expression of the nucleocapsid protein of porcine reproductive and respiratory syndrome virus in soybean seed yields an immunogenic antigenic protein. Planta 235:513–522CrossRefPubMedGoogle Scholar
  61. Weissenbacher-Lang C, Nedorost N, Knecht C, Hennig-Pauka I, Huber M, Voglmayr T, Weissenböck H (2017) Comparison with other respiratory pathogens in two Austrian pig herds. PLoS ONE 12:e0185387CrossRefPubMedPubMedCentralGoogle Scholar
  62. Wensvoort G, de Kluyver EP, Pol JM, Wagenaar F, Moormann RJ, Hulst MM, Bloemraad R, den Besten A, Zetstra T, Terpstra C (1992) Lelystad virus, the cause of porcine epidemic abortion and respiratory syndrome: a review of mystery swine disease research at Lelystad. Vet Microbiol 33:185–193CrossRefPubMedGoogle Scholar
  63. Zhang Q, Yoo D (2015) PRRS virus receptors and their role for pathogenesis. Vet Microbiol 177:229–241CrossRefPubMedGoogle Scholar
  64. Zhou L, Yang H (2010) Porcine reproductive and respiratory syndrome in China. Virus Res 154:31–37CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Centro Nacional de Investigación Disciplinaria en Microbiología Animal (CENID-Microbiología, INIFAP)Palo Alto, CuajimalpaMexico

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