Chimerism pp 119-134 | Cite as

Passenger Lymphocyte Syndrome

  • Nicole L. DraperEmail author
  • Jamie E. Kallan


Passenger lymphocyte syndrome (PLS) is a well-described but infrequent complication of hematopoietic progenitor cell and solid organ transplantation that occurs when viable donor B lymphocytes present within an allograft are passively transferred to a recipient during transplantation. These donor lymphocytes produce antibodies, which mount an immune response directed primarily against recipient red blood cell (RBC) antigens, resulting in antibody-mediated RBC destruction. Donor-derived antiplatelet antibodies can also result in transient thrombocytopenia. Factors affecting the degree of hemolysis or thrombocytopenia are the quantity of transplanted lymphoid tissue present within the transplanted organ, the antibody titer in the donor before transplantation, and the rate of increasing antibody titer in the recipient following transplantation. Hemolysis due to PLS following transplantation can be severe but is generally self-limited.


Passenger lymphocyte syndrome Transplantation-mediated alloimmune thrombocytopenia Hemolysis Solid organ transplant 



Mark R. Hopkins, MD, created Fig. 8.1.


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PathologyUniversity of Colorado School of MedicineAuroraUSA
  2. 2.Transfusion ServicesUniversity of Colorado HospitalAuroraUSA

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