Potential of Tree Endophytes as Sources for New Drug Compounds

  • Mysore V. TejesviEmail author
  • Anna Maria Pirttilä
Part of the Forestry Sciences book series (FOSC, volume 86)


The novel or designer metabolites produced by fungal endophytes are increasingly recognized by natural chemists due to their diverse structures and as candidates for drug discovery and development. Many of the metabolites belong to different classes i.e., alkaloids, benzopyranones, coumarins, chromones, cytochalasines, enniatines, isocoumarin derivatives, quinones, peptides, phenols, phenolic acids, semiquinones, steroids, terpenoids, xanthones and lactones. One of the most widely studied endophytic genera is Pestalotiopsis, from which more than 140 metabolites are reported with antimicrobial, antioxidant and antitumor activities. Here we update on the advances made on identifying bioactive metabolites with drug development potential from endophytic fungi. Furthermore, we look into the most recent innovations on improving the exploitation of endophytic fungi and their products by the pharmaceutical industry. Our main emphasis lies on the anti-infective discovery in the view of developing new drug compounds from endophytic products.



Angiotensin I-converting enzyme


Acquired Immune Deficiency Syndrome


Cell-free metabolic engineering


Denaturing Gradient Gel Electrophoresis


European Agency for the Evaluation of Medicinal Products


Food and Drug Administration


Human immunodeficiency


The half maximal inhibitory concentration


Minimum inhibitory concentration


New Delhi metallo-beta-lactamase


Restriction Fragment Length Polymorphism


Severe acute respiratory syndrome




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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Ecology and GeneticsUniversity of OuluOuluFinland

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