Hematolymphoid System

  • John Choi
  • Jeffery M. Klco
  • Kamran Mirza
Part of the Molecular Pathology Library book series (MPLB)


Hematolymphoid neoplasm is the most common type of pediatric cancer and is classified by morphologic and immunophenotypic similarities to their normal counterparts, by their clinical presentation, and by their genetic mutations. Our understanding of the last is increasing dramatically and forms the basis for the latest subclassification of hematolymphoid neoplasms that provides better prediction of outcome and rationale for altered therapy. This chapter reviews our current classification scheme for pediatric hematolymphoid neoplasm.


Childhood leukemia AML ALL Ph-like ALL CML BCR-ABL1 Leukemia associated with Down syndrome GATA1 Juvenile myelomonocytic leukemia Childhood myelodysplastic syndrome Therapy-related myeloid neoplasms Minimal residual disease Childhood lymphoma Next-generation sequencing NGS 


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PathologySt. Jude Children’s Research HospitalMemphisUSA
  2. 2.Department of Pathology and Laboratory MedicineLoyola University Chicago Stritch School of MedicineMaywoodUSA

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