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Molecular Pathology of Pediatric Renal Tumors

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Precision Molecular Pathology of Neoplastic Pediatric Diseases

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Abstract

Tumors of the kidney comprise approximately 7% of all childhood malignancies. The vast majority are Wilms tumors, which have an overall incidence of approximately 500 cases per year. In recent years, the systematic study of pediatric renal tumors has allowed for more accurate characterization of these different entities, including their histologic appearance and molecular features that aid in risk stratification. In this chapter, we discuss the pathologic and molecular features of the most common pediatric renal tumors, including genetic alterations with diagnostic and prognostic implications.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Nationwide Children’s Hospital, Columbus, OH, USA

    Selene C. Koo MD, PhD

  2. The Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA

    Elizabeth J. Perlman MD

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  1. Selene C. Koo MD, PhD
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  2. Elizabeth J. Perlman MD
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Correspondence to Selene C. Koo MD, PhD .

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Editors and Affiliations

  1. Department of Pathology, University of Utah/ARUP Laboratories, Salt Lake City, Utah, USA

    Larissa V. Furtado

  2. Department of Pathology, University of Chicago, Chicago, Illinois, USA

    Aliya N. Husain

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Koo, S.C., Perlman, E.J. (2018). Molecular Pathology of Pediatric Renal Tumors. In: Furtado, L., Husain, A. (eds) Precision Molecular Pathology of Neoplastic Pediatric Diseases . Molecular Pathology Library. Springer, Cham. https://doi.org/10.1007/978-3-319-89626-7_15

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