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Double Face of eHsp70 in Front of Different Situations

Multiple Role of eHsp70
  • Maria M. Barreca
  • Fabiana Geraci
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 14)

Abstract

The Hsp70 family is one of the best conserved and abundant member of the heat shock proteins (HSP). This family includes several members and in particular one constitutively expressed member (Hsc70) and another one inducibly expressed under several stress conditions (Hsp70). To date, the intracellular functions of Hsp70 are well defined, and increasing evidences establish its roles in the extracellular environment, such as cytoprotection and immunomodulation. Increasing evidences suggest that several cell types are able to release Hsp70 in the extracellular environment, both under physiological and stress conditions. At the same time many release mechanisms have been identified. This chapter briefly reviews recent advances in our understanding on extracellular Hsp70 role in both physiological and pathological conditions. A better comprehension will be useful to take advantage of its potential as a therapeutic target.

Keywords

eHsp70 Hsp70 export Cellular receptors Immune response Cell migration 

Abbreviations

APC

antigen presenting cell

CNS

central nervous system

CSF

cerebrospinal fluid

CTL

cytotoxic T lymphocyte

DC

dendritic cells

EAE

experimental autoimmune encephalomyelitis

ECM

extracellular matrix

ER

endoplasmic reticulum

EV

extracellular vesicle

HSP

heat shock protein

HUVEC

human umbilical vein endothelial cell

LPS

lipopolysaccharide

MBP

myelin basic protein

MHC

major histocompatibility complex;

MS

multiple sclerosis

NF-kB

nuclear factor kB

NK

natural killer

PBL

peripheral blood lymphocyte

ROS

radical oxygen species

TLR

toll like receptor

Notes

Acknowledgements

This research was supported by grants from the University of Palermo.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Biological, Chemical and Pharmaceutical Sciences and TechnologiesUniversity of PalermoPalermoItaly
  2. 2.Euro-Mediterranean Institute of Science and TechnologyPalermoItaly

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