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Implication of HSP70 in the Pathogenesis of Gastric Cancer

  • Prakash Chand Sharma
  • Renu Verma
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 14)

Abstract

Gastric cancer is the third most common cause of cancer linked mortality in the world. Despite recent advances in treatment regimes, effective prognosis and diagnosis of GC is still a formidable task as the disease is asymptomatic in early stages. Heat Shock Proteins (HSP) constitute a class of ubiquitous and highly conserved proteins that show differential expression during different stresses including cancer. HSP70, an important member of the HSP family, regulate various biological processes like protein folding and degradation, apoptosis, and angiogenesis related with tumorigenesis. Differential expression of HSP70 has been explored in tumor versus normal tissues. Upregualtion of HSP70 has been validated in advanced stages making it a future potential prognostic marker in GC. Infection with Helicobacter pylori, a major causative agent of GC, is known to communicate with HSP70 and downregulate its expression. Genetic polymorphism has been correlated with susceptibility to many diseases and association of HSP70 polymorphism in GC is no exception. This chapter deals with various functional roles of HSP70 and its implication in tumorigenesis, particularly gastric cancer.

Keywords

Angiogenesis Apoptosis Gastric cancer Helicobacter pylori HSP70 Protein folding and degradation 

Abbreviations

GC

gastric cancer

H. pylori

Helicobacter pylori

HSF

heat shock factor

HSP

heat shock proteins

IHC

immunohistochemistry

kDA

kilo dalton

RT-PCR

real time – polymerase chain reaction

sHSP

small heat shock proteins

Notes

Acknowledgements

PCS acknowledges a faculty research grant and RV acknowledges short term research fellowship of Guru Gobind Singh Indraprastha University, Delhi.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Prakash Chand Sharma
    • 1
  • Renu Verma
    • 1
  1. 1.University School of BiotechnologyGuru Gobind Singh Indraprastha UniversityNew DelhiIndia

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