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Heat Shock Protein 70 and Cancer

  • Tuoen Liu
  • Shousong Cao
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 14)

Abstract

Heat shock proteins (HSP) constitute a large family of proteins involved in protein folding and maturation and the expressions of HSP are induced by heat shock or other stressors. The major groups, which are classified based on their molecular weight, include HSP27, HSP40, HSP60, HSP70, HSP90, and large HSP (HSP110 and glucose-regulated protein 170). The human HSP70 family is consists of 13 members and five of them have a strong association with cancer. HSP play a significant role in cellular proliferation, differentiation, survival, apoptosis, and carcinogenesis. In this chapter, we thoroughly discussed the roles of HSP70s in cancer biology and pharmacology. The HSP70 proteins have important functions in the molecular mechanisms leading to cancer development, progression, and metastasis. They may also have potential clinical use as biomarkers for cancer diagnosis or assessing disease progression, and as therapeutic targets for cancer therapy. Understanding of the functions and molecular mechanisms of HSP70 proteins is critical for enhancing the accuracy of cancer diagnosis as well as for developing more effective and less toxic chemotherapeutic agents.

Keywords

Biomarker Cancer Carcinogenesis Heat shock protein 70 Therapeutic target 

Abbreviations

5-FU

fluorouracil

ADP

adenosine diphosphate

AIF

apoptosis-inducing factor

AKT

protein kinase B

ALL

acute lymphoid leukemia

AML

acute myelogenous leukemia

AMPK

AMP-activated protein kinase

APAF-1

apoptotic protease activating factor 1

ATF

activating transcription factor

ATP

adenosine triphosphate

ATPase

adenosine triphosphatase

BAG-1

Bcl-2 associated athanogene 1

BAX

Bcl-2 associated X

Bcl-2

B-cell lymphoma-2

Bcl-xL

B-cell lymphoma-extra-large

BIK

Bcl-2 interacting killer

BIP

binding immunoglobulin protein

B-RAF

v-raf murine sarcoma viral oncogene homolog B

CDK

cyclin-dependent kinase

CHIP

carboxyl-terminus of HSP70-interacting protein

CML

chronic myeloid leukemia

C-RAF

v-raf murine sarcoma viral oncogene homolog C

DMC

demethoxycurcumin

EGFR

epidermal growth factor receptor

EMT

epithelial-mesenchymal transition

ER

endoplasmic reticulum

ERK

Ras/extracellular signal-regulated kinase

FDA

Food and Drug Administration

GRP

glucose-regulated protein

HBV

hepatitis B virus

HDAC

histone deacetylases

HER2

human epidermal growth factor receptor 2

HIV

human immunodeficiency virus

HSC

heat-shock cognate protein

HSE

heat shock element

HSF

heat shock factor

HSP

heat shock protein

HUGO

Human Genome Organization

IL

interleukin

JAK

Janus kinase

MAPK

mitogen-activated protein kinase

MCL-1

myeloid cell leukemia 1

MEK

mitogen-activated protein kinase kinase

mTOR

mechanistic target of rapamycin

MTX

methotrexate

NF-κB

nuclear factor NF-κB

NSCLC

non-small cell lung cancer;

oxLDL

oxidative modified low density lipoprotein

PES

phenylethynesulfonamide

PFT

pifithrin

PI3K

phosphatidylinositol-4, 5-bisphosphate 3-kinase

PSA

prostate-specific antigen

SAHA

suberanilohydroxamic acid

SK1

sphingosine kinase 1

STAT

signal transducer and activator of transcription

TGF

transforming growth factor

TNF

tumor necrosis factor;

TNIP1

TNF-α-induced protein 3-interacting protein 1

UBXN2A

UBX Domain Protein 2A

Notes

Acknowledgements

This work was supported by the West Virginia School of Osteopathic Medicine faculty startup funding (T. Liu); and the Distinguished Professor Research Startup Funding (S. Cao) from Southwest Medical University, Lanzhou, Sichuan, China.

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Biomedical SciencesWest Virginia School of Osteopathic MedicineLewisburgUSA
  2. 2.Department of Pharmacology, School of PharmacySouthwest Medical UniversityLuzhouChina

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