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Heat Shock Protein 70 and Cancer

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HSP70 in Human Diseases and Disorders

Part of the book series: Heat Shock Proteins ((HESP,volume 14))

Abstract

Heat shock proteins (HSP) constitute a large family of proteins involved in protein folding and maturation and the expressions of HSP are induced by heat shock or other stressors. The major groups, which are classified based on their molecular weight, include HSP27, HSP40, HSP60, HSP70, HSP90, and large HSP (HSP110 and glucose-regulated protein 170). The human HSP70 family is consists of 13 members and five of them have a strong association with cancer. HSP play a significant role in cellular proliferation, differentiation, survival, apoptosis, and carcinogenesis. In this chapter, we thoroughly discussed the roles of HSP70s in cancer biology and pharmacology. The HSP70 proteins have important functions in the molecular mechanisms leading to cancer development, progression, and metastasis. They may also have potential clinical use as biomarkers for cancer diagnosis or assessing disease progression, and as therapeutic targets for cancer therapy. Understanding of the functions and molecular mechanisms of HSP70 proteins is critical for enhancing the accuracy of cancer diagnosis as well as for developing more effective and less toxic chemotherapeutic agents.

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Abbreviations

5-FU:

fluorouracil

ADP:

adenosine diphosphate

AIF:

apoptosis-inducing factor

AKT:

protein kinase B

ALL:

acute lymphoid leukemia

AML:

acute myelogenous leukemia

AMPK:

AMP-activated protein kinase

APAF-1:

apoptotic protease activating factor 1

ATF:

activating transcription factor

ATP:

adenosine triphosphate

ATPase:

adenosine triphosphatase

BAG-1:

Bcl-2 associated athanogene 1

BAX:

Bcl-2 associated X

Bcl-2:

B-cell lymphoma-2

Bcl-xL:

B-cell lymphoma-extra-large

BIK:

Bcl-2 interacting killer

BIP:

binding immunoglobulin protein

B-RAF:

v-raf murine sarcoma viral oncogene homolog B

CDK:

cyclin-dependent kinase

CHIP:

carboxyl-terminus of HSP70-interacting protein

CML:

chronic myeloid leukemia

C-RAF:

v-raf murine sarcoma viral oncogene homolog C

DMC:

demethoxycurcumin

EGFR:

epidermal growth factor receptor

EMT:

epithelial-mesenchymal transition

ER:

endoplasmic reticulum

ERK:

Ras/extracellular signal-regulated kinase

FDA:

Food and Drug Administration

GRP:

glucose-regulated protein

HBV:

hepatitis B virus

HDAC:

histone deacetylases

HER2:

human epidermal growth factor receptor 2

HIV:

human immunodeficiency virus

HSC:

heat-shock cognate protein

HSE:

heat shock element

HSF:

heat shock factor

HSP:

heat shock protein

HUGO:

Human Genome Organization

IL:

interleukin

JAK:

Janus kinase

MAPK:

mitogen-activated protein kinase

MCL-1:

myeloid cell leukemia 1

MEK:

mitogen-activated protein kinase kinase

mTOR:

mechanistic target of rapamycin

MTX:

methotrexate

NF-κB:

nuclear factor NF-κB

NSCLC:

non-small cell lung cancer;

oxLDL:

oxidative modified low density lipoprotein

PES:

phenylethynesulfonamide

PFT:

pifithrin

PI3K:

phosphatidylinositol-4, 5-bisphosphate 3-kinase

PSA:

prostate-specific antigen

SAHA:

suberanilohydroxamic acid

SK1:

sphingosine kinase 1

STAT:

signal transducer and activator of transcription

TGF:

transforming growth factor

TNF:

tumor necrosis factor;

TNIP1:

TNF-α-induced protein 3-interacting protein 1

UBXN2A:

UBX Domain Protein 2A

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Acknowledgements

This work was supported by the West Virginia School of Osteopathic Medicine faculty startup funding (T. Liu); and the Distinguished Professor Research Startup Funding (S. Cao) from Southwest Medical University, Lanzhou, Sichuan, China.

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Authors and Affiliations

  1. Department of Biomedical Sciences, West Virginia School of Osteopathic Medicine, Lewisburg, WV, USA

    Tuoen Liu

  2. Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China

    Shousong Cao

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  1. Tuoen Liu
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  2. Shousong Cao
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Correspondence to Tuoen Liu .

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Editors and Affiliations

  1. Department of Medicine and Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Punit Kaur

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Liu, T., Cao, S. (2018). Heat Shock Protein 70 and Cancer. In: Asea, A., Kaur, P. (eds) HSP70 in Human Diseases and Disorders. Heat Shock Proteins, vol 14. Springer, Cham. https://doi.org/10.1007/978-3-319-89551-2_5

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