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Suppression of HSP70 Expression by Quercetin and Its Therapeutic Potential Against Cancer

  • Evren Önay Uçar
  • Aslıhan Şengelen
  • Elif Mertoğlu
  • Murat Pekmez
  • Nazlı Arda
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 14)

Abstract

Heat shock response is one of several survival pathways that protects cells against harsh conditions. This response mechanism, which is evolutionarily protected in all organisms, enhances the expression of heat shock proteins (HSP) that show protective properties for cells under stress conditions. High expression of many HSP is observed in cancer, and their functions aides the advancement of disease. It is known that overexpression of HSP70, a member of HSP family, in cancerous cells has been closely associated with tumor cell proliferation, apoptosis inhibition, enhanced migration and metastasis and drug resistance promotion. Therefore, targeting HSP70 in cancer treatment is very important. One of the best-studied inhibitors known for HSP70 is quercetin that is widely distributed flavonoid in the plant kingdom. Several in vivo and in vitro studies have reported the efficacy of quercetin in reducing elevated HSP70 levels in cancer therapy. It has become a focal point as an anticancer agent because of the induction of apoptosis in many different cancer cells. In this chapter, we reviewed the role of HSP70 in different cancer types and the suppressive effect of quercetin on expression of HSP70 family members. Moreover, we emphasized molecular mechanisms targeted by quercetin in cancer and its relationship to Hsp70.

Keywords

Apoptosis Cancer HSP70 Quercetin Stress proteins Therapeutic target 

Abbreviations

Akts (or PKB)

protein kinase B

AMPK

AMP activated protein kinase

CaMKII

calcium/calmodulin-dependent protein kinase II

Cdk

cyclin-dependent kinases

Chk2

checkpoint kinase 2

CK2

casein kinase 2

ER

endoplasmic reticulum

ERK

extracellular signal-regulated kinase

Hsc

heat shock cognate

HSE

heat shock element

HSF

heat shock factor

HSP

heat shock protein

IL-6

interleukin-6

JAK

Janus kinase

JNK

C-Jun N-terminal kinase

MAPK

mitogen-activated protein kinase

MMP

matrix metalloproteinase

PI3K

phosphatidylinositol 3-kinase

pRb

retinoblastoma protein

ROS

reactive oxygen species

RSK2

ribosomal protein S6 kinase 2

S6K1

ribosomal protein S6 kinase beta-1

shRNA

short hairpin RNA

siRNA

small interfering RNA

STAT3

signal transducer and activator of transcription 3

VEGF

vascular endothelial growth factor

Notes

Acknowledgements

This study was supported by the Research Fund of Istanbul University (Project no. 57959 and 24987).

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Evren Önay Uçar
    • 1
  • Aslıhan Şengelen
    • 1
  • Elif Mertoğlu
    • 1
  • Murat Pekmez
    • 1
  • Nazlı Arda
    • 1
  1. 1.Department of Molecular Biology & Genetics, Faculty of ScienceIstanbul UniversityIstanbulTurkey

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