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Heat Shock Protein 70 and Other Heat Shock Proteins in Diseased Retina

  • Ting Zhang
  • Bobak Bahrami
  • Ling Zhu
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 14)

Abstract

Heat shock proteins (HSP) belong to a family of stress-induced proteins essential to cell survival. HSP have multiple protective roles through assistance in protein folding, maintaining mitochondrial homeostasis, suppressing proinflammatory cytokines, resisting ischemic damage and protecting cells from apoptotic and necrotic death. This chapter discusses the important roles of HSP, particularly HSP70 in enhancing the survival of neurons in retinal disease through different pathways. Studies in various retinal cell lines, animal models and human tissue demonstrate altered HSP expression under different stresses and diseases. These findings implicate the critical role of. HSP in the diseased retina as well as providing support for translating the HSP’ cellular defense strategy into therapy to protect and rescue injured retina from different retinal pathology.

Keywords

Age-related macular degeneration Cell death Diabetic retinopathy Glaucoma Heat shock proteins Inflammation Mitochondria Oxidative stress Protein folding 

Abbreviations

AMD

age-related macular degeneration

DR

diabetic retinopathy

GGA

geranylgeranylacetone

HSP

heat shock proteins

LC-MS/MS

liquid chromatography tandem-mass spectrometry

NFκB

nuclear factor-κB

RGCs

retinal ganglion cells

RPE

retinal pigment epithelium

STZ

streptozotocin 

TNF

tumour necrosis factor

VEGF

vascular endothelial growth factor

Notes

Acknowledgements

This work was supported in part by the University of Sydney Postgraduate Award (to B. B.) and Early Career Researcher Kick Start Grant from the Balnaves Foundation and Sydney Medical School (to L. Z.)

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center for Biotherapy, West China HospitalSichuan UniversityChengduPeople’s Republic of China
  2. 2.Save Sight InstituteThe University of SydneySydneyAustralia

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