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Heat Shock Proteins in the Kidney: What Is Known About Their Role in Kidney Disease

  • Shobhana Nayak Rao
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 14)

Abstract

Heat Shock Proteins (HSP) belongs to the family of intracellular proteins that are constitutively expressed and are markedly upregulated by various stressors including heat, oxidative and chemical stress. Expression of HSP helps in numerous reparative processes including the refolding of damaged proteins and removal of irreparably damaged proteins that would accumulate and initiate cellular death or apoptosis. A growing body of evidence in recent times has expanded the role of HSP and defined their physiological and pathological role in various diseases such as neurodegenerative disorders, cancer, ischemic heart disease as well as in kidney diseases. The protective role of HSP in ischemic renal injury has been described recently and HSP impairment has been noted in other forms of kidney injury as well as in post- transplant situation. Further research and better understanding of the role of HSP in prevention of kidney injury will be crucial if translation from the laboratory to patient bedside has to occur. This article aims to be a review of heat shock protein and its relevance to kidney disease.

Keywords

Apoptosis Dialysis Heat shock protein Ischemia reperfusion injury Kidney disease 

Abbreviations

AKI

acute kidney injury

APC

antigen presenting cell

CKD

chronic kidney disease

HSP

heat shock protein

IL

interleukin

PKD

polycystic kidney disease

PLS

peritoneal dialysis fluid

SLE

systemic lupus erythematosus

THP

Tamm- Horsfall Protein

TLR

toll like receptor

TNF

tumor necrosis factor

Notes

Acknowledgements

None

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Shobhana Nayak Rao
    • 1
  1. 1.Department of NephrologyK.S. Hegde Medical Academy Medical Sciences ComplexMangaloreIndia

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